4-hydroxybutanoyl-CoA dehydratase

4-hydroxybutanoyl-CoA dehydratase
Identifiers
EC no.	4.2.1.120
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.120) is an enzyme with systematic name 4-hydroxybutanoyl-CoA hydro-lyase. ^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

4-hydroxybutanoyl-CoA ${\displaystyle \rightleftharpoons }$ (E)-but-3-enoyl-CoA + H₂O

This enzyme contains FAD and a [4Fe-4S] iron-sulfur cluster.

References

1. Bartsch RG, Barker HA (January 1961). "A vinylacetyl isomerase from Clostridium kluyveri". Archives of Biochemistry and Biophysics. 92: 122–32. doi:10.1016/0003-9861(61)90226-0. PMID   13687513.
2. Scherf U, Söhling B, Gottschalk G, Linder D, Buckel W (1994). "Succinate-ethanol fermentation in Clostridium kluyveri: purification and characterisation of 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase". Archives of Microbiology. 161 (3): 239–45. doi:10.1007/bf00248699. PMID   8161284.
3. Scherf U, Buckel W (July 1993). "Purification and properties of an iron-sulfur and FAD-containing 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase from Clostridium aminobutyricum". European Journal of Biochemistry. 215 (2): 421–9. doi:10.1111/j.1432-1033.1993.tb18049.x. PMID   8344309.
4. Müh U, Cinkaya I, Albracht SP, Buckel W (September 1996). "4-Hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: characterization of FAD and iron-sulfur clusters involved in an overall non-redox reaction" . Biochemistry. 35 (36): 11710–8. doi:10.1021/bi9601363. PMID   8794752.
5. Berg IA, Kockelkorn D, Buckel W, Fuchs G (December 2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318 (5857): 1782–6. Bibcode:2007Sci...318.1782B. doi:10.1126/science.1149976. PMID   18079405.

External links

• 4-hydroxybutanoyl-CoA+dehydratase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)