Prephenate dehydratase

prephenate dehydratase
Prephenate dehydratase homotetramer, Paenarthrobacter aurescens
Identifiers
EC no.	4.2.1.51
CAS no.	9044-88-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme prephenate dehydratase (EC 4.2.1.51) catalyzes the chemical reaction: ^{[1] [2]}

prephenic acid

 

 

CO₂ + H₂O

 

CO₂ + H₂O

 

phenylpyruvic acid

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming). This enzyme is also called prephenate hydro-lyase (decarboxylating). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis. ^{[3] [4]}

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QMX.

References

1. Enzyme 4.2.1.51 at KEGG Pathway Database.
2. Cotton RG, Gibson F (1965). "The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase". Biochim. Biophys. Acta. 100: 76–88. doi:10.1016/0304-4165(65)90429-0. PMID   14323651.
3. Cerutti P, Guroff G (1965). "Enzymatic Formation of Phenylpyruvic Acid in Pseudomonas Sp. (Atcc 11299A) and ITS Regulation". J. Biol. Chem. 240 (7): 3034–8. doi: 10.1016/S0021-9258(18)97282-0 . PMID   14342329.
4. Schmidt JC; Zalkin H (1969). "Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium". Biochemistry. 8 (1): 174–181. doi:10.1021/bi00829a025. PMID   4887851.