Phosphogluconate dehydratase

phosphogluconate dehydratase
6-Phosphogluconate dehydratase monomer, Shewanella oneidensis
Identifiers
EC no.	4.2.1.12
CAS no.	9024-33-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

2-keto-3-deoxy-6-phosphogluconate, a product of the reaction catalysed by phosphogluconate dehydratase

The enzyme phosphogluconate dehydratase (EC 4.2.1.12) catalyzes the chemical reaction

6-phospho-D-gluconate ${\displaystyle \rightleftharpoons }$ 2-dehydro-3-deoxy-6-phospho-D-gluconate + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming). Other names in common use include 6-phosphogluconate dehydratase, 6-phosphogluconic dehydrase, gluconate-6-phosphate dehydratase, gluconate 6-phosphate dehydratase, 6-phosphogluconate dehydrase, and 6-phospho-Dgluconate hydro-lyase. This enzyme participates in the Entner–Doudoroff pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2GP4.

References

• MELOCHE HP, WOOD WA (1964). "The Mechanism of 6-Phosphogluconic Dehydrase". J. Biol. Chem. 239 (10): 3505–10. doi: 10.1016/S0021-9258(18)97751-3 . PMID   14245409.