1,5-anhydro-D-fructose dehydratase

1,5-anhydro-D-fructose dehydratase
Identifiers
EC no.	4.2.1.111
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme 1,5-anhydro-D-fructose dehydratase (EC 4.2.1.111) catalyzes the chemical reaction

1,5-anhydro-D-fructose ${\displaystyle \rightleftharpoons }$ 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H₂O

It catalyzes two steps in the anhydrofructose pathway process. ^[1]

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 1,5-anhydro-D-fructose hydro-lyase (ascopyrone-M-forming). Other names in common use include 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydrolyase, 1,5-anhydro-D-arabino-hex-2-ulose dehydratase, AFDH, AF dehydratase, and 1,5-anhydro-D-fructose hydro-lyase.

References

1. IUBMB - Anhydrofructose Pathway

• Yu S, Refdahl C, Lundt I (2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochim. Biophys. Acta. 1672 (2): 120–9. doi:10.1016/j.bbagen.2004.03.004. PMID   15110094.
• Yu S, Fiskesund R (2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochim. Biophys. Acta. 1760 (9): 1314–22. doi:10.1016/j.bbagen.2006.05.007. PMID   16822618.
• Yu S (2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochim. Biophys. Acta. 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID   15716041.

See also

• Anhydrofructose pathway
• Ascopyrone tautomerase
• exo-(1→4)-α-D-glucan lyase