UDP-glucuronate decarboxylase

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UDP-glucuronate decarboxylase
UDP-glucuronate decarboxylase
	UDP-glucuronate decarboxylase 1, dimer, Human
Identifiers
EC no.	4.1.1.35
CAS no.	9024-68-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
Search
PMC	articles
PubMed	articles
NCBI	proteins

Last updated August 27, 2023

The enzyme UDP-glucuronate decarboxylase (EC 4.1.1.35) catalyzes the chemical reaction

UDP-D-glucuronate

\rightleftharpoons

UDP-D-xylose + CO₂

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming). Other names in common use include uridine-diphosphoglucuronate decarboxylase, and UDP-D-glucuronate carboxy-lyase. This enzyme participates in starch and sucrose metabolism and nucleotide sugars metabolism. It employs one cofactor, NAD+.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2B69 and 2BLL.

Related Research Articles

Carboxy-lyases, also known as decarboxylases, are carbon–carbon lyases that add or remove a carboxyl group from organic compounds. These enzymes catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.

In enzymology, an UDP-arabinose 4-epimerase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-glucuronate 4-epimerase is an enzyme that catalyzes the chemical reaction

In enzymology, an UDP-glucuronate 5'-epimerase is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">2-oxoglutarate decarboxylase</span> Class of enzymes

The enzyme 2-oxoglutarate decarboxylase (EC 4.1.1.71) catalyzes the chemical reaction: 2-oxoglutarate $succinate semialdehyde + CO 2$

The enzyme 3-dehydro-L-gulonate-6-phosphate decarboxylase (EC 4.1.1.85) catalyzes the chemical reaction

The enzyme aconitate decarboxylase (EC 4.1.1.6) catalyzes the chemical reaction

<span class="mw-page-title-main">Aminocarboxymuconate-semialdehyde decarboxylase</span>

The enzyme aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) catalyzes the chemical reaction

<span class="mw-page-title-main">Benzoylformate decarboxylase</span>

The enzyme benzoylformate decarboxylase (EC 4.1.1.7) catalyzes the following chemical reaction:

The enzyme dehydro-L-gulonate decarboxylase (EC 4.1.1.34) catalyzes the chemical reaction

<span class="mw-page-title-main">Diphosphomevalonate decarboxylase</span> InterPro Family

Diphosphomevalonate decarboxylase (EC 4.1.1.33), most commonly referred to in scientific literature as mevalonate diphosphate decarboxylase, is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Oxalyl-CoA decarboxylase</span>

The enzyme oxalyl-CoA decarboxylase (OXC) (EC 4.1.1.8), primarily produced by the gastrointestinal bacterium Oxalobacter formigenes, catalyzes the chemical reaction

The enzyme phosphatidylserine decarboxylase (EC 4.1.1.65) catalyzes the chemical reaction

The enzyme phosphonopyruvate decarboxylase (EC 4.1.1.82) catalyzes the chemical reaction

The enzyme UDP-galacturonate decarboxylase (EC 4.1.1.67) catalyzes the chemical reaction

In enzymology, a 1,4-beta-D-xylan synthase is an enzyme that catalyzes the chemical reaction

In enzymology, a glucuronate-1-phosphate uridylyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an UTP—xylose-1-phosphate uridylyltransferase is an enzyme that catalyzes the chemical reaction

UDP-glucuronic acid decarboxylase 1 is an enzyme that in humans is encoded by the UXS1 gene.

David Sidney Feingold was an American biochemist.

References

Ankel H, Feingold DS (1965). "Biosynthesis of uridine diphosphate D-xylose. 1. Uridine diphosphate glucuronate carboxy-lyase of wheat germ". Biochemistry. 4 (11): 2468–2475. doi:10.1021/bi00887a028.

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v t e Carbon–carbon lyases (EC 4.1)
4.1.1: Carboxy-lyases	Acetoacetate decarboxylase Adenosylmethionine decarboxylase Arginine decarboxylase Aromatic L-amino acid decarboxylase Glutamate decarboxylase Histidine decarboxylase Lysine decarboxylase Malonyl-CoA decarboxylase Ornithine decarboxylase Oxaloacetate decarboxylase Phosphoenolpyruvate carboxykinase Phosphoenolpyruvate carboxylase Phosphoribosylaminoimidazole carboxylase Pyrophosphomevalonate decarboxylase Pyruvate decarboxylase RuBisCO Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase Uroporphyrinogen III decarboxylase
4.1.2: Aldehyde-lyases	Fructose-bisphosphate aldolase Aldolase A Aldolase B Aldolase C 2-hydroxyphytanoyl-CoA lyase Threonine aldolase
4.1.3: Oxo-acid-lyases	Isocitrate lyase 3-hydroxy-3-methylglutaryl-CoA lyase
4.1.99: Other	Tryptophanase Photolyase CPD lyase Spore photoproduct lyase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)