Epi-cedrol synthase

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epi-cedrol synthase
Identifiers
EC no. 4.2.3.39
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epi-Cedrol synthase (EC 4.2.3.39, 8-epicedrol synthase, epicedrol synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming). [1] [2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O 8-epi-cedrol + diphosphate

This enzyme is activated by Mg2+.

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Gurjunene, also known as (-)-α-gurjunene, is a natural carbotricyclic sesquiterpene that is most commonly found in gurjun balsam, an essential oil compound extracted from plants of the genus Dipterocarpus. The following reaction that synthesizes gurjunene can be catalyzed by alpha-gurjunene synthase:

(2E,6E)-farnesyl diphosphate (–)-α-gurjunene + diphosphate

References

  1. Mercke P, Crock J, Croteau R, Brodelius PE (September 1999). "Cloning, expression, and characterization of epi-cedrol synthase, a sesquiterpene cyclase from Artemisia annua L". Archives of Biochemistry and Biophysics. 369 (2): 213–22. doi:10.1006/abbi.1999.1358. PMID   10486140.
  2. Hua L, Matsuda SP (September 1999). "The molecular cloning of 8-epicedrol synthase from Artemisia annua". Archives of Biochemistry and Biophysics. 369 (2): 208–12. doi:10.1006/abbi.1999.1357. PMID   10486139.