Indolepyruvate decarboxylase

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indolepyruvate decarboxylase
Identifiers
EC no. 4.1.1.74
CAS no. 9074-92-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

The enzyme indolepyruvate decarboxylase (EC 4.1.1.74) catalyzes the chemical reaction

3-(indol-3-yl)pyruvate 2-(indol-3-yl)acetaldehyde + CO2

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-(indol-3-yl)pyruvate carboxy-lyase [(2-indol-3-yl)acetaldehyde-forming]. Other names in common use include indol-3-yl-pyruvate carboxy-lyase, and 3-(indol-3-yl)pyruvate carboxy-lyase. This enzyme participates in tryptophan metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1OVM.

Related Research Articles

<span class="mw-page-title-main">Pyruvate decarboxylase</span> Class of enzymes

Pyruvate decarboxylase is an enzyme that catalyses the decarboxylation of pyruvic acid to acetaldehyde. It is also called 2-oxo-acid carboxylase, alpha-ketoacid carboxylase, and pyruvic decarboxylase. In anaerobic conditions, this enzyme is participates in the fermentation process that occurs in yeast, especially of the genus Saccharomyces, to produce ethanol by fermentation. It is also present in some species of fish where it permits the fish to perform ethanol fermentation when oxygen is scarce. Pyruvate decarboxylase starts this process by converting pyruvate into acetaldehyde and carbon dioxide. Pyruvate decarboxylase depends on cofactors thiamine pyrophosphate (TPP) and magnesium. This enzyme should not be mistaken for the unrelated enzyme pyruvate dehydrogenase, an oxidoreductase, that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA.

Carboxy-lyases, also known as decarboxylases, are carbon–carbon lyases that add or remove a carboxyl group from organic compounds. These enzymes catalyze the decarboxylation of amino acids, beta-keto acids and alpha-keto acids.

In enzymology, an indolepyruvate C-methyltransferase is an enzyme that catalyzes the chemical reaction

In enzymology, an indolepyruvate ferredoxin oxidoreductase (EC 1.2.7.8) is an enzyme that catalyzes the chemical reaction

In enzymology, an indoleacetaldoxime dehydratase (EC 4.99.1.6) is an enzyme that catalyzes the chemical reaction

The enzyme 2,2-dialkylglycine decarboxylase (pyruvate) (EC 4.1.1.64) catalyzes the chemical reaction

The enzyme 4-carboxymuconolactone decarboxylase (EC 4.1.1.44) catalyzes the chemical reaction

<span class="mw-page-title-main">4-hydroxy-2-oxovalerate aldolase</span> InterPro Family

The enzyme 4-hydroxy-2-oxovalerate aldolase catalyzes the chemical reaction

The enzyme 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase (EC 4.1.1.68) catalyzes the chemical reaction

The enzyme acetolactate decarboxylase (EC 4.1.1.5) catalyzes the chemical reaction

The enzyme acetylenedicarboxylate decarboxylase (EC 4.1.1.78) catalyzes the chemical reaction

<span class="mw-page-title-main">Aminocarboxymuconate-semialdehyde decarboxylase</span>

The enzyme aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) catalyzes the chemical reaction

The enzyme arylmalonate decarboxylase (EC 4.1.1.76) catalyzes the chemical reaction

The enzyme branched-chain-2-oxoacid decarboxylase (EC 4.1.1.72) catalyzes the chemical reaction

In enzymology, a glutaconyl-CoA decarboxylase (EC 4.1.1.70) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">Indole-3-glycerol-phosphate synthase</span> Class of enzymes

The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction

<span class="mw-page-title-main">Methylmalonyl-CoA decarboxylase</span>

In enzymology, a methylmalonyl-CoA decarboxylase (EC 7.2.4.3) is an enzyme that catalyzes the chemical reaction

The enzyme phosphatidylserine decarboxylase (EC 4.1.1.65) catalyzes the chemical reaction

<span class="mw-page-title-main">Sulfinoalanine decarboxylase</span>

The enzyme sulfinoalanine decarboxylase (EC 4.1.1.29) catalyzes the chemical reaction

The enzyme threonine-phosphate decarboxylase (EC 4.1.1.81) catalyzes the chemical reaction

References


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