Phosphopantothenoylcysteine decarboxylase

phosphopantothenoylcysteine decarboxylase
Identifiers
EC no.	4.1.1.36
CAS no.	9024-69-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme phosphopantothenoylcysteine decarboxylase (EC 4.1.1.36) catalyzes the chemical reaction

N-[(R)-4'-phosphopantothenoyl]-L-cysteine ${\displaystyle \rightleftharpoons }$ pantotheine 4'-phosphate + CO₂

This enzyme belongs to the family of lyases, to be specific the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming). This enzyme participates in coenzyme A (CoA) biosynthesis from pantothenic acid.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MVL, 1MVN, and 1QZU.

References

• Brown GM (1958). "Requirement of cytidine triphosphate for the biosynthesis of phosphopantetheine". J. Am. Chem. Soc. 80 (12): 3161. Bibcode:1958JAChS..80.3161B. doi:10.1021/ja01545a062.
• Brown GM (February 1959). "The metabolism of pantothenic acid". The Journal of Biological Chemistry. 234 (2): 370–8. doi: 10.1016/S0021-9258(18)70307-4 . PMID   13630913.