Gluconate dehydratase

gluconate dehydratase
Identifiers
EC no.	4.2.1.39
CAS no.	37290-75-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme gluconate dehydratase (EC 4.2.1.39) catalyzes the chemical reaction

D-gluconate ${\displaystyle \rightleftharpoons }$ 2-dehydro-3-deoxy-D-gluconate + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-gluconate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include D-gluconate dehydratase, and D-gluconate hydro-lyase. This enzyme participates in the pentose phosphate pathway.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1QJ4.

References

• Andreesen JR, Gottschalk G (1969). "The occurrence of a modified Entner-doudoroff pathway in Clostridium aceticum". Arch. Mikrobiol. 69 (2): 160–70. doi:10.1007/BF00409760. PMID   5383859. S2CID   19210429.