Avermitilol synthase

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Avermitilol synthase
Identifiers
EC no. 4.2.3.96
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
PubMed articles
NCBI proteins

Avermitilol synthase (EC 4.2.3.96) is an enzyme with systematic name avermitilol hydrolase (cyclizing, avermitilol-forming). [1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O avermitilol + diphosphate

This enzyme requires Mg2+.

References

  1. Chou WK, Fanizza I, Uchiyama T, Komatsu M, Ikeda H, Cane DE (July 2010). "Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol". Journal of the American Chemical Society. 132 (26): 8850–1. Bibcode:2010JAChS.132.8850C. doi:10.1021/ja103087w. PMC   2904616 . PMID   20536237.