Hydroxymandelonitrile lyase

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hydroxymandelonitrile lyase
Identifiers
EC no. 4.1.2.11
CAS no. 9075-38-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
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Gene Ontology AmiGO / QuickGO
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NCBI proteins

The enzyme hydroxymandelonitrile lyase (EC 4.1.2.11) catalyzes the chemical reaction

(S)-4-hydroxymandelonitrile cyanide + 4-hydroxybenzaldehyde

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (S)-4-hydroxymandelonitrile 4-hydroxybenzaldehyde-lyase (cyanide-forming). Other names in common use include hydroxynitrile lyase, oxynitrilase, Sorghum hydroxynitrile lyase, and (S)-4-hydroxymandelonitrile hydroxybenzaldehyde-lyase. This enzyme participates in cyanoamino acid metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GXS.

Related Research Articles

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<span class="mw-page-title-main">Phenylalanine ammonia-lyase</span>

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The enzyme 2,3-dimethylmalate lyase catalyzes the chemical reaction

<span class="mw-page-title-main">Aminocarboxymuconate-semialdehyde decarboxylase</span>

The enzyme aminocarboxymuconate-semialdehyde decarboxylase (EC 4.1.1.45) catalyzes the chemical reaction

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<span class="mw-page-title-main">Mandelonitrile lyase</span>

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<span class="mw-page-title-main">Methylisocitrate lyase</span>

The enzyme methylisocitrate lyase catalyzes the chemical reaction

<span class="mw-page-title-main">Methylmalonyl-CoA decarboxylase</span>

In enzymology, a methylmalonyl-CoA decarboxylase (EC 7.2.4.3) is an enzyme that catalyzes the chemical reaction

<span class="mw-page-title-main">N-acetylneuraminate lyase</span>

The enzyme N-acetylneuraminate lyase catalyzes the chemical reaction

<span class="mw-page-title-main">Tryptophanase</span> Enzyme that converts tryptophan into indole

The enzyme tryptophanase (EC 4.1.99.1) catalyzes the chemical reaction

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The enzyme cyanide hydratase (EC 4.2.1.66) catalyzes the chemical reaction

The enzyme mannonate dehydratase (EC 4.2.1.8) catalyzes the chemical reaction

<span class="mw-page-title-main">Threonine synthase</span>

The enzyme threonine synthase (EC 4.2.3.1) catalyzes the chemical reaction

<span class="mw-page-title-main">Malate synthase</span> Class of enzymes

In enzymology, a malate synthase (EC 2.3.3.9) is an enzyme that catalyzes the chemical reaction

In enzymology, a cyanohydrin beta-glucosyltransferase is an enzyme that catalyzes the chemical reaction

Aliphatic (R)-hydroxynitrile lyase (EC 4.1.2.46, (R)-HNL, (R)-oxynitrilase, (R)-hydroxynitrile lyase, LuHNL) is an enzyme with systematic name (2R)-2-hydroxy-2-methylbutanenitrile butan-2-one-lyase (cyanide forming). This enzyme catalyses the following chemical reaction:

(S)-hydroxynitrile lyase (EC 4.1.2.47, (S)-cyanohydrin producing hydroxynitrile lyase, (S)-oxynitrilase, (S)-HbHNL, (S)-MeHNL, hydroxynitrile lyase, oxynitrilase, HbHNL, MeHNL, (S)-selective hydroxynitrile lyase, (S)-cyanohydrin carbonyl-lyase (cyanide forming), hydroxynitrilase) is an enzyme with systematic name (S)-cyanohydrin lyase (cyanide forming). This enzyme catalyses the interconversion between cyanohydrins and the carbonyl compounds derived from the cyanohydrin with free cyanide, as in the following two chemical reactions:

References


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