Fumarase is an enzyme that catalyzes the reversible hydration/dehydration of fumarate to malate. Fumarase comes in two forms: mitochondrial and cytosolic. The mitochondrial isoenzyme is involved in the Krebs cycle and the cytosolic isoenzyme is involved in the metabolism of amino acids and fumarate. Subcellular localization is established by the presence of a signal sequence on the amino terminus in the mitochondrial form, while subcellular localization in the cytosolic form is established by the absence of the signal sequence found in the mitochondrial variety.
The enzyme 2-hydroxyisoflavanone dehydratase (EC 4.2.1.105) catalyzes the chemical reaction
The enzyme 2-oxopent-4-enoate hydratase (EC 4.2.1.80) catalyzes the chemical reaction
The enzyme 4-oxalmesaconate hydratase (EC 4.2.1.83) catalyzes the chemical reaction
The enzyme 5-dehydro-4-deoxyglucarate dehydratase (EC 4.2.1.41) catalyzes the chemical reaction
The enzyme ATP-dependent NAD(P)H-hydrate dehydratase catalyzes the chemical reactions
The enzyme cyanamide hydratase (EC 4.2.1.69) catalyzes the chemical reaction
The enzyme D-fuconate dehydratase (EC 4.2.1.67) catalyzes the chemical reaction.
The enzyme dihydroxy-acid dehydratase (EC 4.2.1.9) catalyzes the chemical reaction
The enzyme gluconate dehydratase (EC 4.2.1.39) catalyzes the chemical reaction
The enzyme kievitone hydratase (EC 4.2.1.95) catalyzes the chemical reaction
The enzyme maleate hydratase (EC 4.2.1.31) catalyzes the chemical reaction
The enzyme oleate hydratase (EC 4.2.1.53) catalyzes the chemical reaction
The enzyme(R)-2-methylmalate dehydratase (EC 4.2.1.35) catalyzes the chemical reaction
The enzyme (S)-2-methylmalate dehydratase (EC 4.2.1.34) catalyzes the chemical reaction:
The enzyme sabinene-hydrate synthase (EC 4.2.3.11) catalyzes the chemical reaction
Fumarate lyase belongs to the lyase class of enzymes. These proteins use fumarate as a substrate. They have been shown to share a short conserved sequence around a methionine which is probably involved in the catalytic activity of this type of enzymes.
Enoyl-CoA hydratase 2 is an enzyme with systematic name (3R)-3-hydroxyacyl-CoA hydro-lyase. This enzyme catalyses the following chemical reaction on D-3-hydroxyacyl-CoA
ADP-dependent NAD(P)H-hydrate dehydratase is an enzyme with systematic name (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase . This enzyme catalyses the following chemical reaction
Hydro-lyases are a type of enzyme. As lyases, hydro-lyases cleave various chemical bonds by means other than hydrolysis and oxidation. Examples of specific hydro-lyases include carbonic anhydrase and fumarase.
