4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase

4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase
Identifiers
EC no.	4.1.2.34
CAS no.	86611-90-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase (EC 4.1.2.34) catalyzes the chemical reaction

(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H₂O ${\displaystyle \rightleftharpoons }$ 2-formylbenzoate + pyruvate

This enzyme participates in naphthalene and anthracene degradation.

Nomenclature

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase (pyruvate-forming). Other names in common use include 2'-carboxybenzalpyruvate aldolase, (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate, 2-carboxybenzaldehyde-lyase, and (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-formylbenzoate-lyase.

References

• Barnsley EA (April 1983). "Phthalate pathway of phenanthrene metabolism: formation of 2'-carboxybenzalpyruvate". Journal of Bacteriology. 154 (1): 113–7. doi:10.1128/jb.154.1.113-117.1983. PMC   217437 . PMID   6833175.