Trichodiene synthase

trichodiene synthase
Identifiers
EC no.	4.2.3.6
CAS no.	101915-76-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme trichodiene synthase (EC 4.2.3.6) catalyzes the chemical reaction

(2E,6E)-farnesyl diphosphate ${\displaystyle \rightleftharpoons }$ trichodiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1YJ4, 1YYQ, 1YYR, 1YYS, 1YYT, 1YYU, 2AEK, 2AEL, and 2AET.

References

• Hohn TM, Vanmiddlesworth F (1986). "Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides" . Arch. Biochem. Biophys. 251 (2): 756–61. doi:10.1016/0003-9861(86)90386-3. PMID   3800398.^{[ dead link ]}