Trichodiene synthase

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trichodiene synthase
Identifiers
EC no. 4.2.3.6
CAS no. 101915-76-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

The enzyme trichodiene synthase (EC 4.2.3.6) catalyzes the chemical reaction

(2E,6E)-farnesyl diphosphate trichodiene + diphosphate

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1YJ4, 1YYQ, 1YYR, 1YYS, 1YYT, 1YYU, 2AEK, 2AEL, and 2AET.

Related Research Articles

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Vetispiradiene synthase is an enzyme from Egyptian henbane that catalyzes the following chemical reaction:

Germacradienol synthase (EC 4.2.3.22, germacradienol/germacrene-D synthase, 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase [(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming]) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol-forming). This enzyme catalyses the following chemical reaction

epi-Cedrol synthase (EC 4.2.3.39, 8-epicedrol synthase, epicedrol synthase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (8-epi-cedrol-forming). This enzyme catalyses the following chemical reaction

γ-Humulene synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (γ-humulene-forming). This enzyme catalyses the following chemical reaction

Germacrene C synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (germacrene-C-forming). This enzyme catalyses the following chemical reaction

5-Epiaristolochene synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ( -5-epiaristolochene-forming). This enzyme catalyses the following chemical reaction

(+)-Epicubenol synthase (EC 4.2.3.64, farnesyl pyrophosphate cyclase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epicubenol-forming). This enzyme catalyses the following chemical reaction

β-Selinene cyclase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (β-selinene-forming). This enzyme catalyses the following chemical reaction

Patchoulol synthase (EC 4.2.3.70) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming). This enzyme catalyses the following chemical reaction

Valencene synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valencene-forming). It is a terpene cyclase enzyme responsible for the biosynthesis of valencene, a sesquiterpene, using farnesyl pyrophosphate as its substrate. The first such enzyme was isolated using orange cDNA. This enzyme catalyses the following chemical reaction

(–)-Germacrene D synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ( -germacrene-D-forming). This enzyme catalyses the following chemical reaction

exo-α-Bergamotene synthase (EC 4.2.3.81, trans-α-bergamotene synthase, LaBERS (gene)) is an enzyme with systematic name (2E,6E)-farnesyl diphosphate lyase (cyclizing, (–)-exo-α-bergamotene-forming). This enzyme catalyses the following chemical reaction:

7-epi-α-Selinene synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (7-epi-α-selinene-forming). This enzyme catalyses the following chemical reaction

(+)-β-Caryophyllene synthase is an enzyme with systematic name (2Z,6E)-farnesyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction:

γ-Curcumene synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction

Valerena-4,7(11)-diene synthase is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction

References


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