(S)-norcoclaurine synthase

(S)-norcoclaurine synthase
Identifiers
EC no.	4.2.1.78
CAS no.	79122-01-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme (S)-norcoclaurine synthase (EC 4.2.1.78) catalyzes the chemical reaction

4-hydroxyphenylacetaldehyde + 4-(2-aminoethyl)benzene-1,2-diol (Dopamine) ${\displaystyle \rightleftharpoons }$ (S)-norcoclaurine + H₂O

Biosynthesis of (S)-norcoclaurine from dopamine and 4-hydroxyphenylacetaldehyde

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 4-hydroxyphenylacetaldehyde hydro-lyase [adding dopamine (S)-norcoclaurine-forming]. Other names in common use include (S)-norlaudanosoline synthase, and 4-hydroxyphenylacetaldehyde hydro-lyase (adding dopamine). This enzyme participates in benzylisoquinoline alkaloid biosynthesis.

References

• Stadler R, Zenk MH (1990). "A revision of the generally accepted pathway for the biosynthesis of the benzyltetrahydroisoquinoline reticuline". Liebigs Ann. Chem.: 555–562. doi:10.1002/jlac.1990199001104.
• Stadler R, Kutchan TM, Zenk MH (1989). "(S)-Norcoclaurine is the central intermediate in benzylisoquinoline alkaloid biosynthesis". Phytochemistry . 28 (4): 1083–1086. Bibcode:1989PChem..28.1083S. doi:10.1016/0031-9422(89)80187-6.
• Samanani N, Facchini PJ (2002). "Purification and characterization of norcoclaurine synthase. The first committed enzyme in benzylisoquinoline alkaloid biosynthesis in plants". J. Biol. Chem. 277 (37): 33878–83. doi: 10.1074/jbc.M203051200 . PMID   12107162.