Levopimaradiene synthase

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Levopimaradiene synthase
Identifiers
EC no. 4.2.3.32
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
PubMed articles
NCBI proteins

Levopimaradiene synthase (EC 4.2.3.32, PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]) is an enzyme with systematic name (+)-copalyl-diphosphate diphosphate-lyase (abieta-8(14),12-diene-forming). [1] [2] This enzyme catalyses the following chemical reaction

(+)-copalyl diphosphate abieta-8(14),12-diene + diphosphate

In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides.

References

  1. Schepmann HG, Pang J, Matsuda SP (August 2001). "Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis". Archives of Biochemistry and Biophysics. 392 (2): 263–9. doi:10.1006/abbi.2001.2438. PMID   11488601.
  2. Ro DK, Bohlmann J (August 2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry. 67 (15): 1572–8. Bibcode:2006PChem..67.1572R. doi:10.1016/j.phytochem.2006.01.011. PMID   16497345.