Levopimaradiene synthase

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Levopimaradiene synthase
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EC no. 4.2.3.32
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Levopimaradiene synthase (EC 4.2.3.32, PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]) is an enzyme with systematic name (+)-copalyl-diphosphate diphosphate-lyase (abieta-8(14),12-diene-forming). [1] [2] This enzyme catalyses the following chemical reaction

(+)-copalyl diphosphate abieta-8(14),12-diene + diphosphate

In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides.

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ent-Cassa-12,15-diene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase (ent-cassa-12,15-diene-forming). This enzyme catalyses the following chemical reaction

ent-Sandaracopimaradiene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase [ent-sandaracopimara-8(14),15-diene-forming]. This enzyme catalyses the following chemical reaction

ent-Pimara-8(14),15-diene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase [ent-pimara-8(14),15-diene-forming]. This enzyme catalyses the following chemical reaction

ent-Pimara-9(11),15-diene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction

Stemar-13-ene synthase is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase (stemar-13-ene-forming). This enzyme catalyses the following chemical reaction

Stemod-13(17)-ene synthase is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction

syn-Pimara-7,15-diene synthase is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase (9β-pimara-7,15-diene-forming). This enzyme catalyses the following chemical reaction

Aphidicolan-16β-ol synthase (EC 4.2.3.42, PbACS) is an enzyme with systematic name 9α-copalyl-diphosphate diphosphate-lyase (aphidicolan-16β-ol-forming). This enzyme catalyses the following chemical reaction

Isopimara-7,15-diene synthase is an enzyme with systematic name (+)-copalyl diphosphate-lyase (isopimara-7,15-diene-forming). This enzyme catalyses the following chemical reaction

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Syn-copalyl-diphosphate synthase is an enzyme with systematic name 9alpha-copalyl-diphosphate lyase (decyclizing). This enzyme catalyses the following chemical reaction

References

  1. ↑ Schepmann HG, Pang J, Matsuda SP (August 2001). "Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis". Archives of Biochemistry and Biophysics. 392 (2): 263–9. doi:10.1006/abbi.2001.2438. PMID   11488601.
  2. ↑ Ro DK, Bohlmann J (August 2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry. 67 (15): 1572–8. doi:10.1016/j.phytochem.2006.01.011. PMID   16497345.
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