Aldos-2-ulose dehydratase

Aldos-2-ulose dehydratase
Identifiers
EC no.	4.2.1.110
CAS no.	101920-80-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Aldos-2-ulose dehydratase (EC 4.2.1.110, pyranosone dehydratase, AUDH, 1,5-anhydro-D-fructose dehydratase (microthecin-forming)) is an enzyme with systematic name 1,5-anhydro-D-fructose hydro-lyase (microthecin-forming). ^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

1,5-anhydro-D-fructose ${\displaystyle \rightleftharpoons }$ 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H₂O (overall reaction)

(1a) 1,5-anhydro-D-fructose ${\displaystyle \rightleftharpoons }$ 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H₂O

(1b) 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose ${\displaystyle \rightleftharpoons }$ 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one

This enzyme catalyses two of the steps in the anhydrofructose pathway.

References

1. Yu S, Fiskesund R (September 2006). "The anhydrofructose pathway and its possible role in stress response and signaling". Biochimica et Biophysica Acta (BBA) - General Subjects. 1760 (9): 1314–22. doi:10.1016/j.bbagen.2006.05.007. PMID   16822618.
2. Yu S (May 2005). "Enzymatic description of the anhydrofructose pathway of glycogen degradation II. Gene identification and characterization of the reactions catalyzed by aldos-2-ulose dehydratase that converts 1,5-anhydro-D-fructose to microthecin with ascopyrone M as the intermediate". Biochimica et Biophysica Acta. 1723 (1–3): 63–73. doi:10.1016/j.bbagen.2005.01.004. PMID   15716041.
3. Broberg, A.; Kenne, L.; Pedersén, M. (1996). "Presence of microthecin in the red alga Gracilariopsis lemaneiformis and its formation from 1,5-anhydro-D-fructose". Phytochemistry. 41 (1): 151–154. Bibcode:1996PChem..41..151B. doi:10.1016/0031-9422(95)00587-0.
4. Gabriel J, Volc J, Sedmera P, Daniel G, Kubátová E (1993). "Pyranosone dehydratase from the basidiomycete Phanerochaete chrysosporium: improved purification, and identification of 6-deoxy-D-glucosone and D-xylosone reaction products" . Archives of Microbiology. 160 (1): 27–34. doi:10.1007/BF00258142. PMID   8352649. S2CID   5987101.
5. Yu S, Refdahl C, Lundt I (May 2004). "Enzymatic description of the anhydrofructose pathway of glycogen degradation; I. Identification and purification of anhydrofructose dehydratase, ascopyrone tautomerase and alpha-1,4-glucan lyase in the fungus Anthracobia melaloma". Biochimica et Biophysica Acta. 1672 (2): 120–9. doi:10.1016/j.bbagen.2004.03.004. PMID   15110094.

External links

• Aldos-2-ulose+dehydratase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)