3-dehydroshikimate dehydratase

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3-dehydroshikimate dehydratase
Identifiers
EC no. 4.2.1.118
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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NCBI proteins

3-dehydroshikimate dehydratase (EC 4.2.1.118) is an enzyme with systematic name 3-dehydroshikimate hydro-lyase. [1] [2] This enzyme catalyses the following chemical reaction

3-dehydro-shikimate 3,4-dihydroxybenzoate + H2O

This enzyme catalyses an early step in the biosynthesis of petrobactin.

References

  1. Fox DT, Hotta K, Kim CY, Koppisch AT (November 2008). "The missing link in petrobactin biosynthesis: asbF encodes a (−)-3-dehydroshikimate dehydratase". Biochemistry. 47 (47): 12251–3. doi:10.1021/bi801876q. PMID   18975921.
  2. Pfleger BF, Kim Y, Nusca TD, Maltseva N, Lee JY, Rath CM, Scaglione JB, Janes BK, Anderson EC, Bergman NH, Hanna PC, Joachimiak A, Sherman DH (November 2008). "Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 105 (44): 17133–8. Bibcode:2008PNAS..10517133P. doi: 10.1073/pnas.0808118105 . PMC   2579390 . PMID   18955706.