| dTDP-glucose 4,6-dehydratase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.1.46 | ||||||||
| CAS no. | 37259-54-4 | ||||||||
| Alt. names | RmlB | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) catalyzes the chemical reaction
The first protein structures of a dTDP-glucose 4,6-dehydratase (RmlB) were completed by Jim Thoden in the Hazel Holden lab (University of Wisconsin–Madison) and Simon Allard in the Jim Naismith lab (University of St Andrews). [1] [2] Further structural, mutagenic, and enzymatic studies by both groups, along with important mechanistic work by the W. Wallace Cleland and Perry Frey groups have led to a good understanding of this enzyme. [3] [4] In brief summary, the enzyme is a dimeric protein with a Rossmann fold; it uses the tightly bound coenzyme NAD + for transiently oxidizing the substrate, activating it for the dehydration step. [5] [6]
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include thymidine diphosphoglucose oxidoreductase, TDP-glucose oxidoreductase, RmlB , DESIV, and dTDP-glucose 4,6-hydro-lyase. This enzyme participates in 4 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, polyketide sugar unit biosynthesis, and biosynthesis of vancomycin group antibiotics.
In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase (EC 1.1.1.266) is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-6-deoxy-L-talose 4-dehydrogenase (EC 1.1.1.134) is an enzyme that catalyzes the chemical reaction
In enzymology, a GDP-6-deoxy-D-talose 4-dehydrogenase (EC 1.1.1.135) is an enzyme that catalyzes the chemical reaction
CDP-4-dehydro-6-deoxyglucose reductase (EC 1.17.1.1) is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-4-dehydrorhamnose 3,5-epimerase is an enzyme that catalyzes the chemical reaction
The enzyme altronate dehydratase (EC 4.2.1.7) catalyzes the chemical reaction
The enzyme CDP-glucose 4,6-dehydratase (EC 4.2.1.45) catalyzes the chemical reaction
The enzyme galactonate dehydratase (EC 4.2.1.6) catalyzes the chemical reaction
The enzyme GDP-mannose 4,6-dehydratase (EC 4.2.1.47) catalyzes the chemical reaction
The enzyme gluconate dehydratase (EC 4.2.1.39) catalyzes the chemical reaction
The enzyme L-arabinonate dehydratase (EC 4.2.1.25) catalyzes the chemical reaction
The enzyme phosphogluconate dehydratase (EC 4.2.1.12) catalyzes the chemical reaction
The enzyme UDP-glucose 4,6-dehydratase (EC 4.2.1.76) catalyzes the chemical reaction
In enzymology, a dTDP-4-amino-4,6-dideoxy-D-glucose transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-4-amino-4,6-dideoxygalactose transaminase is an enzyme that catalyzes the chemical reaction
In enzymology, a glucose-1-phosphate thymidylyltransferase is an enzyme that catalyzes the chemical reaction
Nogalamycin is an anthracycline antibiotic produced by the soil bacteria Streptomyces nogalater. It has antitumor properties but it is also highly cardiotoxic. The less cardiotoxic semisynthetic analog menogaril was developed in the 1970s. Currently nogalamycin and menogaril are not used clinically.
Thymidine diphosphate glucose is a nucleotide-linked sugar consisting of deoxythymidine diphosphate linked to glucose. It is the starting compound for the syntheses of many deoxysugars.
DTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+) (EC 1.1.1.339, tll (gene name)) is an enzyme with systematic name dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase. This enzyme catalyses the following chemical reaction
