Bicyclogermacrene synthase

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Bicyclogermacrene synthase
Identifiers
EC no. 4.2.3.100
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
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NCBI proteins

Bicyclogermacrene synthase (EC 4.2.3.100, Ov-TPS4) is an enzyme with systematic name (2E,6E))-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming). [1] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate bicyclogermacrene + diphosphate

The enzyme from oregano ( Origanum vulgare ) gives mainly bicyclogermacrene with Mn2+ as a cofactor.

References

  1. Crocoll C, Asbach J, Novak J, Gershenzon J, Degenhardt J (August 2010). "Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis". Plant Molecular Biology. 73 (6): 587–603. Bibcode:2010PMolB..73..587C. doi:10.1007/s11103-010-9636-1. hdl: 11858/00-001M-0000-0012-A513-2 . PMID   20419468. S2CID   45230098.