Neoabietadiene synthase

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Neoabietadiene synthase
Identifiers
EC no. 4.2.3.132
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Neoabietadiene synthase (EC 4.2.3.132, AgAS, PtTPS-LAS) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, neoabietadiene-forming). [1] [2] [3] This enzyme catalyses the following chemical reaction:

(+)-copalyl diphosphate neoabietadiene + diphosphate

This enzyme is isolated from Abies grandis (grand fir).

Related Research Articles

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<span class="mw-page-title-main">Juvabione</span> Chemical compound

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<span class="mw-page-title-main">Terpene synthase N terminal domain</span> Protein domain

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<span class="mw-page-title-main">Terpene synthase C terminal domain</span> Protein domain

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ent-Isokaurene synthase is an enzyme with systematic name ent-copalyl-diphosphate diphosphate-lyase . This enzyme catalyses the following chemical reaction

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(–)-camphene synthase is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (–)-camphene-forming]. This enzyme catalyses the following chemical reaction

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(–)-β-Pinene synthase (EC 4.2.3.120, β-geraniolene synthase, (–)-(1S,5S)-pinene synthase, geranyldiphosphate diphosphate lyase (pinene forming)) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (–)-β-pinene-forming]. This enzyme catalyses the following chemical reaction

cis-Abienol synthase is an enzyme with systematic name (13E)-8α-hydroxylabd-13-en-15-yl-diphosphate-lyase . This enzyme catalyses the following chemical reaction

References

  1. ↑ Peters RJ, Flory JE, Jetter R, Ravn MM, Lee HJ, Coates RM, Croteau RB (2000). "Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme". Biochemistry. 39 (50): 15592–15602. doi:10.1021/bi001997l. PMID   11112547.
  2. ↑ Zhou K, Gao Y, Hoy JA, Mann FM, Honzatko RB, Peters RJ (February 2012). "Insights into diterpene cyclization from structure of bifunctional abietadiene synthase from Abies grandis". The Journal of Biological Chemistry. 287 (9): 6840–50. doi: 10.1074/jbc.M111.337592 . PMC   3307272 . PMID   22219188.
  3. ↑ Ro DK, Bohlmann J (August 2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry. 67 (15): 1572–8. doi:10.1016/j.phytochem.2006.01.011. PMID   16497345.
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