Tyrosine phenol-lyase

tyrosine phenol-lyase
Identifiers
EC no.	4.1.99.2
CAS no.	9059-31-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme tyrosine phenol-lyase (EC 4.1.99.2) catalyzes the chemical reaction

L-tyrosine + H₂O ${\displaystyle \rightleftharpoons }$ phenol + pyruvate + NH₃

This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is L-tyrosine phenol-lyase (deaminating; pyruvate-forming). Other names in common use include beta-tyrosinase, and L-tyrosine phenol-lyase (deaminating). This enzyme participates in tyrosine metabolism and nitrogen metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, five structures have been solved for this class of enzyme, with PDB accession codes 1C7G, 1TPL, 2EZ1, 2EZ2, and 2TPL.

References

• Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. I. Purification, crystallization, and properties". J. Biol. Chem. 245 (7): 1767–72. doi: 10.1016/S0021-9258(19)77158-0 . PMID   4908868.
• Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K (1970). "Tyrosine phenol lyase. II. Cofactor requirements". J. Biol. Chem. 245 (7): 1773–7. doi: 10.1016/S0021-9258(19)77159-2 . PMID   4908869.