Epi-isozizaene synthase

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epi-isozizaene synthase
Identifiers
EC no. 4.2.3.37
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
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NCBI proteins

epi-Isozizaene synthase (EC 4.2.3.37, SCO5222 protein) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epi-isozizaene-forming). [1] [2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate (+)-epi-isozizaene + diphosphate

This enzyme requires Mg2+ for activity.

References

  1. Lin X, Hopson R, Cane DE (May 2006). "Genome mining in Streptomyces coelicolor: molecular cloning and characterization of a new sesquiterpene synthase". Journal of the American Chemical Society. 128 (18): 6022–3. Bibcode:2006JAChS.128.6022L. doi:10.1021/ja061292s. PMC   2533732 . PMID   16669656.
  2. Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE (March 2008). "Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)". The Journal of Biological Chemistry. 283 (13): 8183–9. doi: 10.1074/jbc.M710421200 . PMC   2276382 . PMID   18234666.