Wee1-like protein kinase

See also: Wee1

WEE1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X8B, 2IN6, 2IO6, 2Z2W, 3BI6, 3BIZ, 3CQE, 3CR0
Identifiers
Aliases	WEE1 , WEE1A, WEE1hu, WEE1 G2 checkpoint kinase
External IDs	OMIM: 193525; MGI: 103075; HomoloGene: 31152; GeneCards: WEE1; OMA:WEE1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 9,573,670 bp [1] End 9,593,457 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 109,721,253 bp [2] End 109,742,493 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone skin of thigh mucosa of paranasal sinus tail of epididymis gastric mucosa buccal mucosa cell embryo ganglionic eminence bronchial epithelial cell skin of abdomen Top expressed in decidua gastrula primitive streak cumulus cell parotid gland endocardial cushion vas deferens pontine nuclei maxillary prominence mandibular prominence More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding nucleotide binding protein tyrosine kinase activity protein kinase activity transferase activity magnesium ion binding non-membrane spanning protein tyrosine kinase activity ATP binding protein binding kinase activity Cellular component nucleolus nucleoplasm cytoplasm nucleus Biological process cell cycle neuron projection morphogenesis establishment of cell polarity cell division G2/M transition of mitotic cell cycle microtubule cytoskeleton organization peptidyl-tyrosine phosphorylation protein phosphorylation phosphorylation mitotic cell cycle G1/S transition of mitotic cell cycle negative regulation of G1/S transition of mitotic cell cycle mitotic cell cycle checkpoint signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7465 22390 Ensembl ENSG00000166483 ENSMUSG00000031016 UniProt P30291 P47810 RefSeq (mRNA) NM_001143976 NM_003390 NM_009516 NM_001355058 RefSeq (protein) NP_001137448 NP_003381 NP_033542 NP_001341987 Location (UCSC) Chr 11: 9.57 – 9.59 Mb Chr 7: 109.72 – 109.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. ^[5]

Function

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. ^[6]

Interactions

Wee1-like protein kinase has been shown to interact with YWHAB ^[7] and PIN1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000166483 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031016 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID   1840647. S2CID   2920330.
6. "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".
7. Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4). UNITED STATES: 211–9. ISSN   1044-9523. PMID   10775038.
8. Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. 12 (5). UNITED STATES: 706–20. doi:10.1101/gad.12.5.706. ISSN   0890-9369. PMC   316589 . PMID   9499405.

Further reading

• Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID   15142377.
• Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024 (1): 153–67. Bibcode:2004NYASA1024..153K. doi:10.1196/annals.1321.013. PMID   15265780. S2CID   23655886.
• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2 11. doi: 10.1186/1742-4690-2-11 . PMC   554975 . PMID   15725353.
• Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi: 10.1038/sj.cr.7290279 . PMID   15780175.
• Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID   15817944.
• Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi: 10.1038/sj.cr.7290370 . PMID   16354571.
• Igarashi M, Nagata A, Jinno S, et al. (1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID   1840647. S2CID   2920330.
• Baldin V, Ducommun B (1995). "Subcellular localisation of human wee1 kinase is regulated during the cell cycle". J. Cell Sci. 108 (6): 2425–32. doi:10.1242/jcs.108.6.2425. PMID   7673359.
• Watanabe N, Broome M, Hunter T (1995). "Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle". EMBO J. 14 (9): 1878–91. doi:10.1002/j.1460-2075.1995.tb07180.x. PMC   398287 . PMID   7743995.
• McGowan CH, Russell P (1995). "Cell cycle regulation of human WEE1". EMBO J. 14 (10): 2166–75. doi:10.1002/j.1460-2075.1995.tb07210.x. PMC   398322 . PMID   7774574.
• Kharbanda S, Yuan ZM, Taneja N, et al. (1994). "p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.". Oncogene. 9 (10): 3005–11. PMID   8084605.
• Heald R, McLoughlin M, McKeon F (1993). "Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase". Cell. 74 (3): 463–74. doi:10.1016/0092-8674(93)80048-J. PMID   8348613. S2CID   12091935.
• McGowan CH, Russell P (1993). "Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15". EMBO J. 12 (1): 75–85. doi:10.1002/j.1460-2075.1993.tb05633.x. PMC   413177 . PMID   8428596.
• Taviaux SA, Demaille JG (1993). "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization". Genomics. 15 (1): 194–6. doi:10.1006/geno.1993.1032. PMID   8432534.
• Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. doi: 10.1074/jbc.272.35.22300 . PMID   9268380.
• Zhou BB, Li H, Yuan J, Kirschner MW (1998). "Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6785–90. Bibcode:1998PNAS...95.6785Z. doi: 10.1073/pnas.95.12.6785 . PMC   22635 . PMID   9618490.
• Taylor WR, DePrimo SE, Agarwal A, et al. (1999). "Mechanisms of G2 arrest in response to overexpression of p53". Mol. Biol. Cell. 10 (11): 3607–22. doi:10.1091/mbc.10.11.3607. PMC   25646 . PMID   10564259.
• Wang Y, Jacobs C, Hook KE, et al. (2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4): 211–9. PMID   10775038.
• Cichutek A, Brueckmann T, Seipel B, et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)". Cytogenet. Cell Genet. 93 (3–4): 277–83. doi:10.1159/000056998. PMID   11528126. S2CID   25807985.
• Elder RT, Yu M, Chen M, et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi: 10.1006/viro.2001.1007 . PMID   11531413.

External links

• WEE1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)