Wee1-like protein kinase

WEE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X8B, 2IN6, 2IO6, 2Z2W, 3BI6, 3BIZ, 3CQE, 3CR0
Identifiers
Aliases	WEE1 , WEE1A, WEE1hu, WEE1 G2 checkpoint kinase
External IDs	OMIM: 193525 MGI: 103075 HomoloGene: 31152 GeneCards: WEE1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	9,593,457 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	109,742,493 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; embryo; ; ganglionic eminence; ; bronchial epithelial cell; ; skin of abdomen; ; corpus epididymis; ; gallbladder; ; lactiferous duct; ; mucosa of urinary bladder; ; stromal cell of endometrium;
	Top expressed in
	primitive streak; ; cumulus cell; ; parotid gland; ; endocardial cushion; ; vas deferens; ; pontine nuclei; ; maxillary prominence; ; internal carotid artery; ; foot; ; ureter;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding ; nucleotide binding ; protein tyrosine kinase activity ; protein kinase activity ; transferase activity ; magnesium ion binding ; non-membrane spanning protein tyrosine kinase activity ; ATP binding ; protein binding ; kinase activity ;
Cellular component	nucleolus ; nucleoplasm ; cytoplasm ; nucleus ;
Biological process	cell cycle ; neuron projection morphogenesis ; establishment of cell polarity ; cell division ; G2/M transition of mitotic cell cycle ; microtubule cytoskeleton organization ; peptidyl-tyrosine phosphorylation ; protein phosphorylation ; phosphorylation ; mitotic cell cycle ; G1/S transition of mitotic cell cycle ; negative regulation of G1/S transition of mitotic cell cycle ; mitotic cell cycle checkpoint signaling ;
	Sources:Amigo / QuickGO
Orthologs
	7465
	22390
	ENSG00000166483
	ENSMUSG00000031016
	P30291
	P47810
	NM_001143976 ; NM_003390
	NM_009516 ; NM_001355058
	NP_001137448 ; NP_003381
	NP_033542 ; NP_001341987
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene.^[5]

Function

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.^[6]

Interactions

Wee1-like protein kinase has been shown to interact with YWHAB ^[7] and PIN1.^[8]

Related Research Articles

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates ; phosphorylation of these proteins leads to cell cycle progression.

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.

M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the cell division cycle 25 homolog A (CDC25A) gene.

M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene.

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform is an enzyme regulator that in humans is encoded by the PPP2R2A gene.

14-3-3 protein beta/alpha is a protein that in humans is encoded by the YWHAB gene.

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.

Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B is an enzyme that in humans is encoded by the PPP2R4 gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the PPP2R5D gene. Mutations in PPP2R5D cause Jordan's Syndrome.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform is an enzyme that in humans is encoded by the PPP2R5B gene.

Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK3 gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform is an enzyme that in humans is encoded by the PPP2R5E gene.

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase also known as Myt1 kinase is an enzyme that in humans is encoded by the PKMYT1 gene.

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe. Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166483 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031016 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647. S2CID 2920330.
↑ "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".
↑ Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. UNITED STATES. 11 (4): 211–9. ISSN 1044-9523. PMID 10775038.
↑ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589 . PMID 9499405.

External links

WEE1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166483 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031016 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1840647-5] Igarashi M, Nagata A, Jinno S, Suto K, Okayama H (September 1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. Bibcode:1991Natur.353...80I. doi:10.1038/353080a0. PMID 1840647. S2CID 2920330.

[entrez-6] "Entrez Gene: WEE1 WEE1 homolog (S. pombe)".

[pmid10775038-7] Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. UNITED STATES. 11 (4): 211–9. ISSN 1044-9523. PMID 10775038.

[pmid9499405-8] Shen, M; Stukenberg P T; Kirschner M W; Lu K P (March 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589 . PMID 9499405.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)