RPS6KA2

RPS6KA2
Identifiers
Aliases	RPS6KA2 , HU-2, MAPKAPK1C, RSK, RSK3, S6K-alpha, S6K-alpha2, p90-RSK3, pp90RSK3, p90RSK2, ribosomal protein S6 kinase A2
External IDs	OMIM: 601685; MGI: 1342290; HomoloGene: 100680; GeneCards: RPS6KA2; OMA:RPS6KA2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q27 Start 166,409,364 bp [1] End 166,906,451 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A1|17 4.7 cM Start 7,437,514 bp [2] End 7,570,714 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior olivary nucleus lower lobe of lung internal globus pallidus dorsal motor nucleus of vagus nerve inferior ganglion of vagus nerve C1 segment optic nerve right lung corpus callosum superior vestibular nucleus Top expressed in granulocyte muscle of thigh neural layer of retina tail of embryo superior frontal gyrus dentate gyrus of hippocampal formation granule cell primary visual cortex genital tubercle lens ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding protein binding protein serine/threonine/tyrosine kinase activity ATP binding magnesium ion binding kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity Cellular component cytoplasm cytosol nucleoplasm nucleus Biological process phosphorylation negative regulation of cell cycle protein phosphorylation positive regulation of apoptotic process negative regulation of cell population proliferation signal transduction intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6196 20112 Ensembl ENSG00000071242 ENSMUSG00000023809 UniProt Q15349 Q9WUT3 RefSeq (mRNA) NM_001006932 NM_021135 NM_001318936 NM_001318937 NM_001318938 NM_011299 RefSeq (protein) NP_001006933 NP_001305865 NP_001305866 NP_001305867 NP_066958 NP_035429 Location (UCSC) Chr 6: 166.41 – 166.91 Mb Chr 17: 7.44 – 7.57 Mb PubMed search [3] [4]
Wikidata
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Ribosomal protein S6 kinase alpha-2 is an enzyme that in humans is encoded by the RPS6KA2 gene. ^{[5] [6]}

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine and threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. ^[6]

Interactions

RPS6KA2 has been shown to interact with MAPK3 ^{[7] [8]} and MAPK1. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000071242 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000023809 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M (Apr 1994). "Human rsk isoforms: cloning and characterization of tissue-specific expression". Am J Physiol. 266 (2 Pt 1): C351–9. doi:10.1152/ajpcell.1994.266.2.C351. PMID   8141249.
6. "Entrez Gene: RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2".
7. Roux PP, Richards Stephanie A, Blenis John (Jul 2003). "Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity". Mol. Cell. Biol. 23 (14). United States: 4796–804. doi:10.1128/MCB.23.14.4796-4804.2003. ISSN   0270-7306. PMC   162206 . PMID   12832467.
8. Zhao Y, Bjorbaek C, Moller D E (Nov 1996). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. 271 (47). UNITED STATES: 29773–9. doi: 10.1074/jbc.271.47.29773 . ISSN   0021-9258. PMID   8939914.

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID   1602151.
• Zhao Y, Bjørbaek C, Weremowicz S, et al. (1995). "RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation". Mol. Cell. Biol. 15 (8): 4353–63. doi:10.1128/MCB.15.8.4353. PMC   230675 . PMID   7623830.
• Wong EV, Schaefer AW, Landreth G, Lemmon V (1996). "Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1". J. Biol. Chem. 271 (30): 18217–23. doi: 10.1074/jbc.271.30.18217 . PMID   8663493.
• Xing J, Ginty DD, Greenberg ME (1996). "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science. 273 (5277): 959–63. Bibcode:1996Sci...273..959X. doi:10.1126/science.273.5277.959. PMID   8688081. S2CID   22226803.
• Zhao Y, Bjorbaek C, Moller DE (1997). "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". J. Biol. Chem. 271 (47): 29773–9. doi: 10.1074/jbc.271.47.29773 . PMID   8939914.
• Fukunaga R, Hunter T (1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC   1169795 . PMID   9155018.
• del Peso L, González-García M, Page C, et al. (1997). "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science. 278 (5338): 687–9. Bibcode:1997Sci...278..687D. doi:10.1126/science.278.5338.687. PMID   9381178.
• Deak M, Clifton AD, Lucocq LM, Alessi DR (1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". EMBO J. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC   1170775 . PMID   9687510.
• Du K, Montminy M (1999). "CREB is a regulatory target for the protein kinase Akt/PKB". J. Biol. Chem. 273 (49): 32377–9. doi: 10.1074/jbc.273.49.32377 . PMID   9829964.
• Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW (1999). "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". J. Biol. Chem. 274 (5): 2893–8. doi: 10.1074/jbc.274.5.2893 . PMID   9915826.
• Jensen CJ, Buch MB, Krag TO, et al. (1999). "90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1". J. Biol. Chem. 274 (38): 27168–76. doi: 10.1074/jbc.274.38.27168 . PMID   10480933.
• Schimenti JC (2000). "ORFless, intronless, and mutant transcription units in the mouse t complex responder (Tcr) locus". Mamm. Genome. 10 (10): 969–76. doi:10.1007/s003359901142. PMID   10501965. S2CID   23157540.
• Scheid MP, Schubert KM, Duronio V (1999). "Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase". J. Biol. Chem. 274 (43): 31108–13. doi: 10.1074/jbc.274.43.31108 . PMID   10521512.
• Tan Y, Demeter MR, Ruan H, Comb MJ (2000). "BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival". J. Biol. Chem. 275 (33): 25865–9. doi: 10.1074/jbc.M004199200 . PMID   10837486.
• Lizcano JM, Morrice N, Cohen P (2001). "Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155". Biochem. J. 349 (Pt 2): 547–57. doi:10.1042/0264-6021:3490547. PMC   1221178 . PMID   10880354.
• Datta SR, Katsov A, Hu L, et al. (2000). "14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation". Mol. Cell. 6 (1): 41–51. doi: 10.1016/S1097-2765(00)00006-X . PMID   10949026.
• Gudi T, Casteel DE, Vinson C, et al. (2001). "NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation". Oncogene. 19 (54): 6324–33. doi:10.1038/sj.onc.1204007. PMID   11175347. S2CID   20150481.
• Willard FS, Crouch MF (2001). "MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit". Cell. Signal. 13 (9): 653–64. doi:10.1016/S0898-6568(01)00185-1. PMID   11495723.
• Schinelli S, Zanassi P, Paolillo M, et al. (2001). "Stimulation of endothelin B receptors in astrocytes induces cAMP response element-binding protein phosphorylation and c-fos expression via multiple mitogen-activated protein kinase signaling pathways". J. Neurosci. 21 (22): 8842–53. doi:10.1523/JNEUROSCI.21-22-08842.2001. PMC   6762276 . PMID   11698596.