PFTK1

CDK14
Identifiers
Aliases	CDK14 , PFTAIRE1, PFTK1, cyclin-dependent kinase 14, cyclin dependent kinase 14
External IDs	OMIM: 610679; MGI: 894318; HomoloGene: 7888; GeneCards: CDK14; OMA:CDK14 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q21.13 Start 90,466,424 bp [1] End 91,210,590 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 A1|5 2.61 cM Start 4,853,391 bp [2] End 5,470,312 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in postcentral gyrus Region I of hippocampus proper pars compacta pars reticulata lateral nuclear group of thalamus entorhinal cortex Brodmann area 10 superior frontal gyrus Brodmann area 46 tendon of biceps brachii Top expressed in cingulate gyrus habenula medial dorsal nucleus amygdala mammillary body dentate gyrus lateral geniculate nucleus anterior amygdaloid area pontine nuclei medial geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cyclin-dependent protein serine/threonine kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding cyclin binding Cellular component membrane plasma membrane cytoplasmic cyclin-dependent protein kinase holoenzyme complex nucleus cytoplasm cytosol Biological process phosphorylation regulation of canonical Wnt signaling pathway Wnt signaling pathway cell division protein phosphorylation G2/M transition of mitotic cell cycle cell cycle regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5218 18647 Ensembl ENSG00000058091 ENSMUSG00000028926 UniProt O94921 O35495 RefSeq (mRNA) NM_001287135 NM_001287136 NM_001287137 NM_012395 NM_011074 NM_001310448 RefSeq (protein) NP_001274064 NP_001274065 NP_001274066 NP_036527 NP_001297377 NP_035204 Location (UCSC) Chr 7: 90.47 – 91.21 Mb Chr 5: 4.85 – 5.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase PFTAIRE-1 is an enzyme that in humans is encoded by the CDK14 gene. ^{[5] [6] [7]}

Interactions

PFTK1 has been shown to interact with SEPT8. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000058091 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028926 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lazzaro MA, Albert PR, Julien JP (Jul 1997). "A novel cdc2-related protein kinase expressed in the nervous system". J Neurochem. 69 (1): 348–64. doi: 10.1046/j.1471-4159.1997.69010348.x . PMID   9202329. S2CID   41686721.
6. Yang T, Chen JY (Apr 2001). "Identification and cellular localization of human PFTAIRE1". Gene. 267 (2): 165–72. doi:10.1016/S0378-1119(01)00391-2. PMID   11313143.
7. "Entrez Gene: PFTK1 PFTAIRE protein kinase 1".
8. Yang, Tao; Gao Yan-Kun; Chen Jiang-Ye (Jul 2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4). China: 520–5. ISSN   0582-9879. PMID   12098780.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi: 10.1093/dnares/5.6.355 . PMID   10048485.
• Yang T, Gao YK, Chen JY (2002). "KIAA0202, a human septin family member, interacting with hPFTAIRE1". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao. 34 (4): 520–5. PMID   12098780.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID   15761153. S2CID   39457788.
• Gao Y, Jiang M, Yang T, et al. (2006). "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins". Cell Res. 16 (6): 539–47. doi: 10.1038/sj.cr.7310071 . PMID   16775625.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Shu F, Lv S, Qin Y, et al. (2007). "Functional characterization of human PFTK1 as a cyclin-dependent kinase". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9248–53. Bibcode:2007PNAS..104.9248S. doi: 10.1073/pnas.0703327104 . PMC   1890480 . PMID   17517622.
• Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Res. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC   1891335 . PMID   17567994.