TTK (gene)

TTK
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2X9E, 2ZMC, 2ZMD, 3CEK, 3DBQ, 3GFW, 3H9F, 3HMN, 3HMO, 3HMP, 3VQU, 3W1F, 3WYX, 3WYY, 3WZJ, 3WZK, 4B94, 4BHZ, 4BI0, 4BI1, 4BI2, 4C4E, 4C4G, 4C4H, 4C4I, 4C4J, 4CV8, 4CV9, 4CVA, 4D2S, 4H7X, 4H7Y, 4JS8, 4JT3, 4O6L, 5AP0, 5AP1, 5AP2, 5AP3, 5AP4, 5AP5, 5AP6, 5AP7, 5EI2, 5EHY, 5EH0, 5EI6, 4ZEG, 5EI8
Identifiers
Aliases	TTK , CT96, ESK, MPH1, MPS1, MPS1L1, PYT, TTK protein kinase
External IDs	OMIM: 604092; MGI: 1194921; HomoloGene: 2489; GeneCards: TTK; OMA:TTK - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q14.1 Start 80,003,887 bp [1] End 80,042,527 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 E2 Start 83,716,742 bp [2] End 83,754,442 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone gonad testicle ganglionic eminence sperm trabecular bone right testis left testis bone marrow Top expressed in zygote primary oocyte genital tubercle tail of embryo maxillary prominence secondary oocyte mandibular prominence epiblast spermatocyte spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity protein serine/threonine/tyrosine kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity nucleotide binding protein kinase activity protein binding ATP binding protein homodimerization activity kinetochore binding Cellular component spindle membrane cytoplasm kinetochore nucleus Biological process chromosome separation mitotic spindle organization positive regulation of pathway-restricted SMAD protein phosphorylation spindle organization mitotic spindle assembly checkpoint signaling positive regulation of cell population proliferation protein phosphorylation phosphorylation mitotic cell cycle checkpoint signaling peptidyl-tyrosine phosphorylation female meiosis chromosome segregation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation meiotic spindle assembly checkpoint signaling protein localization to kinetochore protein localization to chromosome protein autophosphorylation protein localization to meiotic spindle midzone chromosome segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7272 22137 Ensembl ENSG00000112742 ENSMUSG00000038379 UniProt P33981 P35761 RefSeq (mRNA) NM_001166691 NM_003318 NM_001110265 NM_001284272 NM_009445 RefSeq (protein) NP_001160163 NP_003309 NP_001103735 NP_001271201 NP_033471 Location (UCSC) Chr 6: 80 – 80.04 Mb Chr 9: 83.72 – 83.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein kinase TTK also known as Mps1 is an enzyme that in humans is encoded by the TTK gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000112742 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038379 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D (Aug 1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J Biol Chem. 267 (22): 16000–6. doi: 10.1016/S0021-9258(19)49633-6 . PMID   1639825.
6. "Entrez Gene: TTK TTK protein kinase".

Further reading

• Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members". Protein Phosphorylation Part A: Protein Kinases: Assays, Purification, Antibodies, Functional Analysis, Cloning, and Expression. Methods in Enzymology. Vol. 200. pp. 38–62. doi:10.1016/0076-6879(91)00126-H. ISBN   978-0-12-182101-2. PMID   1956325.
• Lindberg RA, Fischer WH, Hunter T (1993). "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene. 8 (2): 351–9. PMID   7678926.
• Lauzé E, Stoelcker B, Luca FC, et al. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. doi:10.1002/j.1460-2075.1995.tb07154.x. PMC   398258 . PMID   7737118.
• Cahill DP, da Costa LT, Carson-Walter EB, et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi: 10.1006/geno.1999.5831 . PMID   10366450.
• Weinmann AS, Yan PS, Oberley MJ, et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC   155318 . PMID   11799066.
• Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002). "Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication". EMBO J. 21 (7): 1723–32. doi:10.1093/emboj/21.7.1723. PMC   125937 . PMID   11927556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Liu ST, Chan GK, Hittle JC, et al. (2003). "Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores". Mol. Biol. Cell. 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMC   153128 . PMID   12686615.
• Fisk HA, Mattison CP, Winey M (2004). "Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 14875–80. doi: 10.1073/pnas.2434156100 . PMC   299837 . PMID   14657364.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. Bibcode:2004FEBSL.572...51D. doi: 10.1016/j.febslet.2004.06.092 . PMID   15304323. S2CID   8403635.
• Wei JH, Chou YF, Ou YH, et al. (2005). "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68". J. Biol. Chem. 280 (9): 7748–57. doi: 10.1074/jbc.M410152200 . PMID   15618221.
• Camacho E, Beà S, Salaverría I, et al. (2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer. 118 (2): 357–63. doi: 10.1002/ijc.21370 . PMID   16080195. S2CID   7968793.
• Leng M, Chan DW, Luo H, et al. (2006). "MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11485–90. Bibcode:2006PNAS..10311485L. doi: 10.1073/pnas.0601828103 . PMC   1518802 . PMID   16864798.
• Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite Sensitivity of TP53 Mutant and Basal Breast Cancers to a Dose-Dense Epirubicin−Cyclophosphamide Regimen". PLOS Med. 4 (3): e90. doi: 10.1371/journal.pmed.0040090 . PMC   1831731 . PMID   17388661.
• Zhu S, Wang W, Clarke DC, Liu X (2007). "Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling". J. Biol. Chem. 282 (25): 18327–38. doi: 10.1074/jbc.M700636200 . PMID   17452325.
• Kanai M, Ma Z, Izumi H, et al. (2007). "Physical and functional interaction between mortalin and Mps1 kinase". Genes Cells. 12 (6): 797–810. doi: 10.1111/j.1365-2443.2007.01091.x . PMID   17573779. S2CID   342866.
• Mattison CP, Old WM, Steiner E, et al. (2007). "Mps1 activation loop autophosphorylation enhances kinase activity". J. Biol. Chem. 282 (42): 30553–61. doi: 10.1074/jbc.M707063200 . PMID   17728254.