Cyclin-dependent kinase 10

CDK10
Identifiers
Aliases	CDK10 , PISSLRE, cyclin-dependent kinase 10, cyclin dependent kinase 10, ALSAS
External IDs	OMIM: 603464 MGI: 2448549 HomoloGene: 55769 GeneCards: CDK10
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q24.3 Start 89,680,737 bp [1] End 89,696,354 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 E1 Start 123,951,581 bp [2] End 123,958,989 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right lobe of thyroid gland left lobe of thyroid gland anterior pituitary body of pancreas right lobe of liver body of stomach canal of the cervix skin of abdomen minor salivary gland Top expressed in superior frontal gyrus spermatocyte otolith organ utricle hand lip yolk sac lens esophagus cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cyclin-dependent protein kinase activity protein binding ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity protein serine/threonine kinase activity Cellular component mediator complex ciliary basal body cytoplasm cytoskeleton cell projection nucleus Biological process traversing start control point of mitotic cell cycle phosphorylation positive regulation of MAPK cascade negative regulation of cell population proliferation protein phosphorylation peptidyl-threonine phosphorylation regulation of actin cytoskeleton organization negative regulation of cilium assembly cell projection organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8558 234854 Ensembl ENSG00000185324 ENSMUSG00000033862 UniProt Q15131 Q3UMM4 RefSeq (mRNA) NM_001098533 NM_001160367 NM_003674 NM_052987 NM_052988 NM_194444 NM_194446 RefSeq (protein) NP_001092003 NP_001153839 NP_443713 NP_443714 NP_919426 NP_919428 Location (UCSC) Chr 16: 89.68 – 89.7 Mb Chr 8: 123.95 – 123.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites. ^[7]

Interactions

Cyclin-dependent kinase 10 has been shown to interact with ETS2. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000185324 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033862 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Graña X, Claudio PP, De Luca A, Sang N, Giordano A (Jul 1994). "PISSLRE, a human novel CDC2-related protein kinase". Oncogene. 9 (7): 2097–103. PMID   8208557.
6. Brambilla R, Draetta G (Oct 1994). "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene. 9 (10): 3037–41. PMID   8084611.
7. "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10".
8. Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID   11313931. S2CID   22792083.

Further reading

• Li S, MacLachlan TK, De Luca A, Claudio PP, Condorelli G, Giordano A (1995). "The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle". Cancer Res. 55 (18): 3992–5. PMID   7664269.
• Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Heubner K, Croce CM (1995). "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. PMID   7882308.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Crawford J, Ianzano L, Savino M, Whitmore S, Cleton-Jansen AM, Settasatian C, d'apolito M, Seshadri R, Pronk JC, Auerbach AD, Verlander PC, Mathew CG, Tipping AJ, Doggett NA, Zelante L, Callen DF, Savoia A (1999). "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer". Genomics. 56 (1): 90–7. doi:10.1006/geno.1998.5676. PMID   10036189.
• Sergère JC, Thuret JY, Le Roux G, Carosella ED, Leteurtre F (2000). "Human CDK10 gene isoforms". Biochem. Biophys. Res. Commun. 276 (1): 271–7. doi:10.1006/bbrc.2000.3395. PMID   11006117.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Kasten M, Giordano A (2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–8. doi:10.1038/sj.onc.1204295. PMID   11313931. S2CID   22792083.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Kéri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi: 10.1074/mcp.T600062-MCP200 . hdl: 10033/19756 . PMID   17192257.

External links

• CDK10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)