CUL7

CUL7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JNG
Identifiers
Aliases	CUL7 , 3M1, KIAA0076, dJ20C7.5, cullin 7, CUL-7
External IDs	OMIM: 609577 MGI: 1913765 HomoloGene: 56683 GeneCards: CUL7
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.1 Start 43,037,617 bp [1] End 43,053,943 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 C Start 46,961,263 bp [2] End 46,975,290 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium pituitary gland anterior pituitary right uterine tube right adrenal gland right lobe of thyroid gland canal of the cervix left adrenal gland left lobe of thyroid gland ganglionic eminence Top expressed in saccule yolk sac otic placode belly cord internal carotid artery external carotid artery molar vas deferens dermis calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding ubiquitin protein ligase binding Cellular component cytoplasm cytosol centrosome Golgi apparatus microtubule organizing center Cul7-RING ubiquitin ligase complex perinuclear region of cytoplasm anaphase-promoting complex 3M complex cytoskeleton Biological process Golgi organization ubiquitin-dependent protein catabolic process placenta development mitotic cytokinesis proteolysis vasculogenesis IRE1-mediated unfolded protein response positive regulation of dendrite morphogenesis protein ubiquitination epithelial to mesenchymal transition viral process microtubule cytoskeleton organization regulation of mitotic nuclear division post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9820 66515 Ensembl ENSG00000044090 ENSMUSG00000038545 UniProt Q14999 Q8VE73 RefSeq (mRNA) NM_001168370 NM_014780 NM_001374872 NM_001374873 NM_001374874 NM_025611 RefSeq (protein) NP_001161842 NP_055595 NP_001361801 NP_001361802 NP_001361803 NP_079887 Location (UCSC) Chr 6: 43.04 – 43.05 Mb Chr 17: 46.96 – 46.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene. ^{[5] [6] [7]}

Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000044090 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038545 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6. doi: 10.1073/pnas.252646399 . PMC   139190 . PMID   12481031.
6. Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60. Bibcode:2003PNAS..100.9855A. doi: 10.1073/pnas.1733908100 . PMC   187864 . PMID   12904573.
7. "Entrez Gene: CUL7 cullin 7".

Further reading

• Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene". Cancer Res. 67 (20): 9616–22. doi: 10.1158/0008-5472.CAN-07-0644 . PMID   17942889.
• Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. Bibcode:2007PNAS..10411388J. doi: 10.1073/pnas.0609467104 . PMC   2040908 . PMID   17586686.
• Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi: 10.1158/0008-5472.CAN-06-3241 . PMID   17332328.
• Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi: 10.1074/jbc.M611297200 . PMID   17298945.
• Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID   16875676.
• Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function". Oncogene. 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID   16547496. S2CID   36894787.
• Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID   16142236. S2CID   44003147.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi: 10.1016/S0960-9822(00)80021-4 . PMID   10531037. S2CID   14341845.
• Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.

External links

• GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
• OMIM entries entry on 3-M syndrome
• Human CUL7 genome location and CUL7 gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q14999 (Human Cullin-7) at the PDBe-KB .