ETS2

Last updated

ETS2
Protein ETS2 PDB 1k78.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ETS2 , ETS2IT1, ETS proto-oncogene 2, transcription factor
External IDs OMIM: 164740; MGI: 95456; HomoloGene: 3838; GeneCards: ETS2; OMA:ETS2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256295
NM_005239

NM_011809

RefSeq (protein)

NP_001243224
NP_005230

NP_035939

Location (UCSC) Chr 21: 38.81 – 38.82 Mb Chr 16: 95.5 – 95.52 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene. [5] [6] The protein encoded by this gene belongs to the ETS family of transcription factors. [5] It has been found to play a key role in the development of inflammatory bowel disease. [7] [8]

Contents

Interactions

ETS2 has been shown to interact with:

Clinical significance

ETS2 has been linked to a variety of diseases, including Takayasu's arteritis, inflammatory bowel disease, primary sclerosing cholangitis, and ankylosing spondylitis, all associated with a region on chromosome 21 at 21q22. [13]

Related Research Articles

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<span class="mw-page-title-main">ETS1</span> Protein-coding gene in the species Homo sapiens

Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.

<span class="mw-page-title-main">MYBL2</span> Protein-coding gene in the species Homo sapiens

Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.

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<span class="mw-page-title-main">SPI1</span> Protein-coding gene in the species Homo sapiens

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.

<span class="mw-page-title-main">COP9 constitutive photomorphogenic homolog subunit 5</span> Protein-coding gene in the species Homo sapiens

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<i>ERG</i> (gene) Protein-coding gene in the species Homo sapiens

ERG is an oncogene. ERG is a member of the ETS family of transcription factors. The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family regulate embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis.

<span class="mw-page-title-main">MST1R</span> Protein-coding gene in the species Homo sapiens

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.

<span class="mw-page-title-main">ETV1</span> Protein-coding gene in the species Homo sapiens

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.

<span class="mw-page-title-main">ELK4</span> Protein-coding gene in the species Homo sapiens

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

<i>ERF</i> (gene) Protein-coding gene in the species Homo sapiens

ETS domain-containing transcription factor ERF is a protein that in humans is encoded by the ERF gene.

<span class="mw-page-title-main">VRK1</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.

<span class="mw-page-title-main">ELK3</span> Protein-coding gene in humans

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.

<span class="mw-page-title-main">RPS6KA4</span> Enzyme found in humans

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

<span class="mw-page-title-main">ETS transcription factor family</span> Protein family

In the field of molecular biology, the ETSfamily is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.

SAP1A is one of a family of proteins that contains a unique DNA binding domain termed the ETS domain.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000157557 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022895 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Dwyer J, Li H, Xu D, Liu JP (Oct 2007). "Transcriptional regulation of telomerase activity: roles of the Ets transcription factor family". Annals of the New York Academy of Sciences. 1114 (1): 36–47. Bibcode:2007NYASA1114...36D. doi:10.1196/annals.1396.022. PMID   17986575. S2CID   44532648.
  6. "Entrez Gene: ETS2 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)".
  7. Chen Y, Ying Y, Wang M, Ma C, Jia M, Shi L, et al. (January 2023). "A distal super-enhancer activates oncogenic ETS2 via recruiting MECOM in inflammatory bowel disease and colorectal cancer". Cell Death & Disease. 14 (1): 8. doi:10.1038/s41419-022-05513-1. PMC   9822945 . PMID   36609474.
  8. Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, et al. (June 2024). "A disease-associated gene desert directs macrophage inflammation through ETS2". Nature. 630 (8016): 447–456. Bibcode:2024Natur.630..447S. doi: 10.1038/s41586-024-07501-1 . PMC   11168933 . PMID   38839969.
  9. 1 2 Basuyaux JP, Ferreira E, Stéhelin D, Butticè G (October 1997). "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". The Journal of Biological Chemistry. 272 (42): 26188–26195. doi: 10.1074/jbc.272.42.26188 . PMID   9334186.
  10. Kasten M, Giordano A (April 2001). "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene. 20 (15): 1832–1838. doi: 10.1038/sj.onc.1204295 . PMID   11313931.
  11. Dudek H, Tantravahi RV, Rao VN, Reddy ES, Reddy EP (February 1992). "Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1291–1295. Bibcode:1992PNAS...89.1291D. doi: 10.1073/pnas.89.4.1291 . PMC   48435 . PMID   1741383.
  12. Wei G, Schaffner AE, Baker KM, Mansky KC, Ostrowski MC (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression". Anticancer Research. 23 (3A): 2173–2178. PMID   12894593.
  13. Stankey CT, Bourges C, Haag LM, Turner-Stokes T, Piedade AP, Palmer-Jones C, et al. (June 2024). "A disease-associated gene desert directs macrophage inflammation through ETS2". Nature. 630 (8016): 447–456. Bibcode:2024Natur.630..447S. doi:10.1038/s41586-024-07501-1. PMC   11168933 . PMID   38839969.

Further reading