ZNF644

ZNF644
Identifiers
Aliases	ZNF644 , BM-005, MYP21, NatF, ZEP-2, zinc finger protein 644
External IDs	OMIM: 614159; MGI: 1277212; HomoloGene: 12971; GeneCards: ZNF644; OMA:ZNF644 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p22.2 Start 90,915,298 bp [1] End 91,022,272 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 E5|5 51.43 cM Start 106,616,739 bp [2] End 106,697,287 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon ventricular zone ganglionic eminence tibialis anterior muscle mucosa of ileum testicle epithelium of colon gonad corpus callosum bone marrow cell Top expressed in genital tubercle tail of embryo Gonadal ridge spermatocyte spermatid medial ganglionic eminence extensor digitorum longus muscle cardiac muscle tissue of left ventricle maxillary prominence lobe of cerebellum More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84146 52397 Ensembl ENSG00000122482 ENSMUSG00000049606 UniProt Q9H582 n/a RefSeq (mRNA) NM_016620 NM_032186 NM_201269 NM_026856 NM_001363318 NM_001363319 NM_001363320 NM_001363321 NM_001363322 NM_001363323 RefSeq (protein) NP_057704 NP_115562 NP_958357 n/a Location (UCSC) Chr 1: 90.92 – 91.02 Mb Chr 5: 106.62 – 106.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zing finger protein 644 (ZNF644) also known as zinc finger motif enhancer-binding protein 2 (Zep-2) is a protein that in humans is encoded by the ZNF644 gene. ^[5]

Clinical relevance

Mutations in the ZNF644 gene have been found in sporadic cases of high myopia. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000122482 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049606 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: zinc finger protein 644".
6. Shi, Yi (2011). "Exome Sequencing Identifies ZNF644 Mutations in High Myopia". PLOS Genetics. 7 (6) e1002084. doi: 10.1371/journal.pgen.1002084 . PMC   3111487 . PMID   21695231.

Further reading

• Zabaneh D, Balding DJ (2010). "A genome-wide association study of the metabolic syndrome in Indian Asian men". PLOS ONE. 5 (8) e11961. Bibcode:2010PLoSO...511961Z. doi: 10.1371/journal.pone.0011961 . PMC   2915922 . PMID   20694148.
• Mulligan P, Westbrook TF, Ottinger M, et al. (2008). "CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation". Mol. Cell. 32 (5): 718–26. doi:10.1016/j.molcel.2008.10.025. PMC   6595072 . PMID   19061646.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.