LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene. [5] [6]
LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene. [5] [6]
Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin. [7]
LMX1A has been shown to interact with TCF3 [8] and LHX3. [9]
LIM homeobox transcription factor 1-beta, also known as LMX1B, is a protein which in humans is encoded by the LMX1B gene.
Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene.
PDX1, also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.
LIM domain only 2, also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.
LIM domain-binding protein 1 is a protein that in humans is encoded by the LDB1 gene.
LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.
Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the ISL1 gene.
PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene.
Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.
Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.
Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.
Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.
Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.
Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.
LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.
Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.
LIM homeobox 1 is a protein that in humans is encoded by the LHX1 gene. This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for control of differentiation and development of neural and lymphoid cells. It is also key in development of renal and urogenital systems and is required for normal organogenesis. A similar protein in mice is an essential regulator of the vertebrate head organizer.
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.
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