RFX2

Last updated
RFX2
Identifiers
Aliases RFX2 , regulatory factor X2
External IDs OMIM: 142765 MGI: 106583 HomoloGene: 30980 GeneCards: RFX2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000635
NM_134433

NM_009056
NM_027787

RefSeq (protein)

NP_000626
NP_602309

NP_033082
NP_082063

Location (UCSC) Chr 19: 5.99 – 6.2 Mb Chr 17: 57.08 – 57.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene. [5] [6]

Contents

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000087903 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024206 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B (Sep 1992). "The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19". Genomics. 13 (4): 1307–10. doi:10.1016/0888-7543(92)90052-T. PMID   1505960.
  6. 1 2 "Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.