FOXF1

Last updated
FOXF1
Identifiers
Aliases FOXF1 , ACDMPV, FKHL5, FREAC1, forkhead box F1
External IDs OMIM: 601089 MGI: 1347470 HomoloGene: 1114 GeneCards: FOXF1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001451

NM_010426

RefSeq (protein)

NP_001442

NP_034556

Location (UCSC) Chr 16: 86.51 – 86.52 Mb Chr 8: 121.08 – 121.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Forkhead box protein F1 (FOXF1) is a protein that in humans is encoded by the FOXF1 gene. [5] [6] [7]

Contents

Function

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. FOX1 protein is important in the development of the pulmonary mesenchyme and the development of the gastrointestinal trac t [8] .

Related Research Articles

FOXproteins are a family of transcription factors that play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Many FOX proteins are important to embryonic development. FOX proteins also have pioneering transcription activity by being able to bind condensed chromatin during cell differentiation processes.

FOXO3 Protein-coding gene in the species Homo sapiens

Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the FOXO3 gene.

JUNB

Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Forkhead box C1

Forkhead box C1, also known as FOXC1, is a protein which in humans is encoded by the FOXC1 gene.

FOXM1

Forkhead box protein M1 is a protein that in humans is encoded by the FOXM1 gene. The protein encoded by this gene is a member of the FOX family of transcription factors. Its potential as a target for future cancer treatments led to it being designated the 2010 Molecule of the Year.

ETV1

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.

MMP16

Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.

ELK4

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

FOXG1

Forkhead box protein G1 is a protein that in humans is encoded by the FOXG1 gene.

IL36B

Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the IL36B gene.

DYRK1B

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.

FOXE1

Forkhead box protein E1 is a protein that in humans is encoded by the FOXE1 gene.

LMX1A

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.

FOXD4

Forkhead box protein D4 is a protein that in humans is encoded by the FOXD4 gene.

MYLK Gene of the immunoglobulin superfamily

Myosin light chain kinase, smooth muscle also known as kinase-related protein (KRP) or telokin is an enzyme that in humans is encoded by the MYLK gene.

FOXE3

Forkhead box protein E3 (FOXE3) also known as forkhead-related transcription factor 8 (FREAC-8) is a protein that in humans is encoded by the FOXE3 gene located on the short arm of chromosome 1.

FOXI1

Forkhead box I1 is a protein that in humans is encoded by the FOXI1 gene.

FOXJ1

Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene. It is a member of the Forkhead/winged helix (FOX) family of transcription factors that is involved in ciliogenesis. FOXJ1 is expressed in ciliated cells of the lung, choroid plexus, reproductive tract, embryonic kidney and pre-somite embryo stage.

Forkhead box d1

Forkhead box D1 is a protein that in humans is encoded by the FOXD1 gene. Forkhead d1 is a kidney expressed transcription factor maps at the chromosome 5 at position 5q12—q13, identified in Drosophila forkhead protein and mammalian HNF3 transcription factor. The name of was derived from two spiked head structures in the embryos of Drosophila forkhead mutant. It belong to transcription factor family that displays remarkable functional diversity and involved in a wide variety of biological processes. The most commonly used synonyms for Forkhead D1 are, FOX D1, FREAC-4 and BF2.

FOXF2

Forkhead box protein F2 is a protein that in humans is encoded by the FOXF2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000103241 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042812 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics. 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID   8825632.
  6. Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal. 13 (20): 5002–12. doi:10.1002/j.1460-2075.1994.tb06827.x. PMC   395442 . PMID   7957066.
  7. "Entrez Gene: FOXF1 forkhead box F1".
  8. "FOXF1 gene: MedlinePlus Genetics". medlineplus.gov. Retrieved 2021-06-10.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.