HOXC12

HOXC12
Identifiers
Aliases	HOXC12 , HOC3F, HOX3, HOX3F, homeobox C12
External IDs	OMIM: 142975 MGI: 96194 HomoloGene: 7769 GeneCards: HOXC12
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.13 Start 53,954,903 bp [1] End 53,958,956 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15 F3|15 58.01 cM Start 102,845,192 bp [2] End 102,847,044 bp [2]
RNA expression pattern Bgee Top expressed in sural nerve popliteal artery subcutaneous adipose tissue adrenal gland zone of skin adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3228	15421
Ensembl	ENSG00000123407	ENSMUSG00000050328
UniProt	P31275	Q8K5B8
RefSeq (mRNA)	NM_173860	NM_010463
RefSeq (protein)	NP_776272	NP_034593
Location (UCSC)	Chr 12: 53.95 – 53.96 Mb	Chr 15: 102.85 – 102.85 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene. ^[5]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000123407 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050328 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Homeobox C12" . Retrieved 2011-11-11.

Further reading

• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (February 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID   11857506.
• Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
• McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (December 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC   335308 . PMID   2574852.
• Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (October 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters. 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID   9357979. S2CID   26075369.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.