TCF7

TCF7
Identifiers
Aliases	TCF7 , TCF-1, transcription factor 7 (T-cell specific, HMG-box), transcription factor 7
External IDs	OMIM: 189908 MGI: 98507 HomoloGene: 135816 GeneCards: TCF7
Gene location (Human)
Chr.	Chromosome 5 (human)
End	134,151,865 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	52,283,014 bp
RNA expression pattern
	Top expressed in
	thymus; ; periodontal fiber; ; lymph node; ; right uterine tube; ; cecum; ; appendix; ; blood; ; cardia; ; pancreatic ductal cell; ; superficial temporal artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding ; DNA binding ; GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity ; GO:0001948 protein binding ; GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific ; beta-catenin binding ; GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	transcription regulator complex ; nucleus ; nucleoplasm ; nuclear body ;
Biological process	cellular response to interleukin-4 ; regulation of transcription, DNA-templated ; T cell receptor V(D)J recombination ; negative regulation of transcription by RNA polymerase II ; embryonic hindgut morphogenesis ; Wnt signaling pathway ; transcription, DNA-templated ; canonical Wnt signaling pathway involved in negative regulation of apoptotic process ; embryonic genitalia morphogenesis ; regulation of cell population proliferation ; immune response ; neural tube development ; embryonic digestive tract morphogenesis ; alpha-beta T cell differentiation ; beta-catenin-TCF complex assembly ; regulation of transcription by RNA polymerase II ; canonical Wnt signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	6932
	21414
	ENSG00000081059
	ENSMUSG00000000782
	P36402
	Q00417
NM_001134851 ; NM_001134852 ; NM_003202 ; NM_201632 ; NM_201634 ;
	NM_213648 ; NM_001346425 ; NM_001346450 ; NM_001366502
	NM_009331 ; NM_001313981
NP_001128323 ; NP_001333354 ; NP_001333379 ; NP_003193 ; NP_963963 ;
	NP_963965 ; NP_998813 ; NP_001353431
	NP_001300910 ; NP_033357
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 23, 2022

Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000081059 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000782 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization". J. Biol. Chem. 267 (12): 8530–6. doi: 10.1016/S0021-9258(18)42476-3 . PMID 1569101.
van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box". EMBO J. 10 (1): 123–32. doi:10.1002/j.1460-2075.1991.tb07928.x. PMC 452620 . PMID 1989880.
Castrop J, van Wichen D, Koomans-Bitter M, et al. (1995). "The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes". Blood. 86 (8): 3050–9. doi: 10.1182/blood.V86.8.3050.3050 . PMID 7579399.
Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA". Biochim. Biophys. Acta. 1263 (2): 169–72. doi:10.1016/0167-4781(95)00108-s. PMID 7640309.
Van de Wetering M, Castrop J, Korinek V, Clevers H (1996). "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties". Mol. Cell. Biol. 16 (3): 745–52. doi:10.1128/mcb.16.3.745. PMC 231054 . PMID 8622675.
Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse". Mol. Cell. Biol. 18 (3): 1248–56. doi:10.1128/MCB.18.3.1248. PMC 108837 . PMID 9488439.
Roose J, Molenaar M, Peterson J, et al. (1998). "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors". Nature. 395 (6702): 608–12. Bibcode:1998Natur.395..608R. doi:10.1038/26989. PMID 9783587. S2CID 4347003.
Roose J, Huls G, van Beest M, et al. (1999). "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1". Science. 285 (5435): 1923–6. doi:10.1126/science.285.5435.1923. PMID 10489374.
Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Res. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284 . PMID 11266540.
Batlle E, Henderson JT, Beghtel H, et al. (2002). "Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB". Cell. 111 (2): 251–63. doi: 10.1016/S0092-8674(02)01015-2 . PMID 12408869. S2CID 10103038.
Noble JA, White AM, Lazzeroni LC, et al. (2003). "A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes". Diabetes. 52 (6): 1579–82. doi: 10.2337/diabetes.52.6.1579 . PMID 12765974.
Ioannidis V, Kunz B, Tanamachi DM, et al. (2003). "Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1". J. Immunol. 171 (2): 769–75. doi: 10.4049/jimmunol.171.2.769 . PMID 12847244.
Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway". J. Biol. Chem. 279 (17): 17232–40. doi: 10.1074/jbc.M307801200 . PMID 14960582.
Smith SS, Patterson T, Pauza ME (2005). "Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes". J. Immunol. 174 (7): 3897–905. doi: 10.4049/jimmunol.174.7.3897 . PMID 15778344.
Willinger T, Freeman T, Herbert M, et al. (2006). "Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo". J. Immunol. 176 (3): 1439–46. doi: 10.4049/jimmunol.176.3.1439 . PMID 16424171.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000081059 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000000782 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

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TCF7

Related Research Articles

References

Further reading