LBX1

LBX1
Identifiers
Aliases	LBX1 , HPX-6, HPX6, LBX1H, homeobox, ladybird homeobox 1, CCHS3
External IDs	OMIM: 604255 MGI: 104867 HomoloGene: 4784 GeneCards: LBX1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.32 Start 101,226,994 bp [1] End 101,229,463 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 C3 Start 45,221,123 bp [2] End 45,224,251 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue right lung frontal lobe dorsolateral prefrontal cortex salivary gland integument Brodmann area 9 minor salivary gland integument Top expressed in triceps brachii muscle ankle vastus lateralis muscle gastrocnemius muscle tibialis anterior muscle skeletal muscle tissue soleus muscle secondary oocyte knee joint urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus transcription regulator complex Biological process multicellular organism development heart looping anatomical structure morphogenesis cell differentiation muscle organ development neuron fate commitment spinal cord motor neuron differentiation regulation of transcription, DNA-templated negative regulation of neuron differentiation neuron fate determination transcription, DNA-templated nervous system development negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10660 16814 Ensembl ENSG00000138136 ENSMUSG00000025216 UniProt P52954 P52955 RefSeq (mRNA) NM_006562 NM_010691 RefSeq (protein) NP_006553 NP_034821 Location (UCSC) Chr 10: 101.23 – 101.23 Mb Chr 19: 45.22 – 45.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene. ^{[5] [6]}

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes.

In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138136 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025216 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jagla K, Dolle P, Mattei MG, Jagla T, Schuhbaur B, Dretzen G, Bellard F, Bellard M (Jul 1996). "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes". Mech Dev. 53 (3): 345–56. doi: 10.1016/0925-4773(95)00450-5 . PMID   8645601. S2CID   19021832.
6. "Entrez Gene: LBX1 ladybird homeobox 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• de Mollerat XJ, Gurrieri F, Morgan CT, et al. (2004). "A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24". Hum. Mol. Genet. 12 (16): 1959–71. doi: 10.1093/hmg/ddg212 . PMID   12913067.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kozmik Z, Holland LZ, Schubert M, et al. (2001). "Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm". Genesis. 29 (4): 172–9. doi:10.1002/gene.1021. PMID   11309850. S2CID   7730828.
• Moretti P, Simmons P, Thomas P, et al. (1994). "Identification of homeobox genes expressed in human haemopoietic progenitor cells". Gene. 144 (2): 213–9. doi:10.1016/0378-1119(94)90380-8. PMID   7518789.