HIVEP2

HIVEP2
Identifiers
Aliases	HIVEP2 , HIV-EP2, MBP-2, MIBP1, SHN2, ZAS2, ZNF40B, human immunodeficiency virus type I enhancer binding protein 2, MRD43
External IDs	OMIM: 143054 MGI: 1338076 HomoloGene: 4900 GeneCards: HIVEP2
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q24.2 Start 142,751,467 bp [1] End 142,956,698 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 A2 Start 13,966,075 bp [2] End 14,151,374 bp [2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • sequence-specific DNA binding • metal ion binding • nucleic acid binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component • nucleus • nucleoplasm Biological process • multicellular organism development • regulation of transcription, DNA-templated • transcription by RNA polymerase II • signal transduction • transcription, DNA-templated • regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3097	15273
Ensembl	ENSG00000010818	ENSMUSG00000015501
UniProt	P31629	Q3UHF7
RefSeq (mRNA)	NM_006734	NM_010437 NM_001358782 NM_001358783
RefSeq (protein)	NP_006725	NP_034567 NP_001345711 NP_001345712
Location (UCSC)	Chr 6: 142.75 – 142.96 Mb	Chr 10: 13.97 – 14.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor HIVEP2 is a protein that in humans is encoded by the HIVEP2 gene. ^{[5] [6] [7]}

Function

Members of the ZAS family, such as ZAS2 (HIVEP2), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000010818 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015501 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Sudo T, Ozawa K, Soeda EI, Nomura N, Ishii S (January 1992). "Mapping of the human gene for the human immunodeficiency virus type 1 enhancer binding protein HIV-EP2 to chromosome 6q23-q24". Genomics. 12 (1): 167–70. doi:10.1016/0888-7543(92)90423-P. PMID   1733857.
6. Nomura N, Zhao MJ, Nagase T, Maekawa T, Ishizaki R, Tabata S, Ishii S (May 1991). "HIV-EP2, a new member of the gene family encoding the human immunodeficiency virus type 1 enhancer-binding protein. Comparison with HIV-EP1/PRDII-BF1/MBP-1". The Journal of Biological Chemistry. 266 (13): 8590–4. doi: 10.1016/S0021-9258(18)93015-2 . PMID   2022670.
7. "Entrez Gene: HIVEP2 human immunodeficiency virus type I enhancer binding protein 2".

Further reading

• van 't Veer LJ, Lutz PM, Isselbacher KJ, Bernards R (October 1992). "Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 8971–5. Bibcode:1992PNAS...89.8971V. doi: 10.1073/pnas.89.19.8971 . PMC   50046 . PMID   1409593.
• Rustgi AK, Van 't Veer LJ, Bernards R (November 1990). "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties". Proceedings of the National Academy of Sciences of the United States of America. 87 (22): 8707–10. Bibcode:1990PNAS...87.8707R. doi: 10.1073/pnas.87.22.8707 . PMC   55028 . PMID   2247438.
• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Dörflinger U, Pscherer A, Moser M, Rümmele P, Schüle R, Buettner R (May 1999). "Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain". Molecular and Cellular Biology. 19 (5): 3736–47. doi:10.1128/mcb.19.5.3736. PMC   84194 . PMID   10207097.
• Zajac-Kaye M, Ben-Baruch N, Kastanos E, Kaye FJ, Allegra C (February 2000). "Induction of Myc-intron-binding polypeptides MIBP1 and RFX1 during retinoic acid-mediated differentiation of haemopoietic cells". The Biochemical Journal. 345 (3): 535–41. doi:10.1042/0264-6021:3450535. PMC   1220788 . PMID   10642512.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

External links

• HIVEP2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.