KLF7

Last updated
KLF7
Identifiers
Aliases KLF7 , UKLF, Kruppel-like factor 7 (ubiquitous), Kruppel like factor 7
External IDs OMIM: 604865 MGI: 1935151 HomoloGene: 2751 GeneCards: KLF7
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270942
NM_001270943
NM_001270944
NM_003709

NM_033563

RefSeq (protein)

NP_001257871
NP_001257872
NP_001257873
NP_003700

NP_291041

Location (UCSC) Chr 2: 207.07 – 207.17 Mb Chr 1: 64.07 – 64.16 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kruppel-like factor 7 (ubiquitous), also known as KLF7, is a protein which in humans is encoded by the KLF7 gene. [5] [6]

Contents

This protein is a member of the Kruppel-like family of transcription factors. [7]

Related Research Articles

In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family.

<span class="mw-page-title-main">KLF6</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.

<span class="mw-page-title-main">KLF4</span> Protein-coding gene in the species Homo sapiens

Kruppel-like factor 4 is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer. It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

<span class="mw-page-title-main">CTBP1</span>

C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2.

<span class="mw-page-title-main">KLF5</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

<span class="mw-page-title-main">KLF2</span> Protein-coding gene in the species Homo sapiens

Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19. It is in the Krüppel-like factor family of zinc finger transcription factors, and it has been implicated in a variety of biochemical processes in the human body, including lung development, embryonic erythropoiesis, epithelial integrity, T-cell viability, and adipogenesis.

<span class="mw-page-title-main">TRIM24</span>

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

<i>NFIC</i> (gene) Protein-coding gene in the species Homo sapiens

Nuclear factor 1 C-type is a protein that in humans is encoded by the NFIC gene.

<span class="mw-page-title-main">KLF10</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

<span class="mw-page-title-main">KLF11</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 11 is a protein that in humans is encoded by the KLF11 gene.

<span class="mw-page-title-main">KLF13</span> Protein-coding gene in the species Homo sapiens

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.

<span class="mw-page-title-main">Sp2 transcription factor</span> Protein-coding gene in the species Homo sapiens

Transcription factor Sp2 is a protein that in humans is encoded by the SP2 gene.

<span class="mw-page-title-main">KLF12</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

<span class="mw-page-title-main">KLF9</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 9 is a protein that in humans is encoded by the KLF9 gene. Previously known as Basic Transcription Element Binding Protein 1, Klf9 is part of the Sp1 C2H2-type zinc finger family of transcription factors. Several previous studies showed Klf9-related regulation of animal development, including cell differentiation of B cells, keratinocytes, and neurons. Klf9 is also a key transcriptional regulator for uterine endometrial cell proliferation, adhesion, and differentiation, all factors that are essential during the process of pregnancy and are turned off during tumorigenesis.

<span class="mw-page-title-main">ZNF143</span> Protein-coding gene

Zinc finger protein 143 is a protein that in humans is encoded by the ZNF143 gene.

<span class="mw-page-title-main">KLF8</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

<span class="mw-page-title-main">KLF3</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

<span class="mw-page-title-main">ZNF268</span>

Zinc finger protein 268 is a protein that in humans is encoded by the ZNF268 gene.

<span class="mw-page-title-main">KLF14</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene. The corresponding Klf14 mouse gene is known as Sp6.

<span class="mw-page-title-main">KLF15</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000118263 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025959 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: KLF7 Kruppel-like factor 7 (ubiquitous)".
  6. Matsumoto N, Laub F, Aldabe R, Zhang W, Ramirez F, Yoshida T, Terada M (October 1998). "Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors". The Journal of Biological Chemistry. 273 (43): 28229–37. doi: 10.1074/jbc.273.43.28229 . PMID   9774444.
  7. Bieker JJ (September 2001). "Krüppel-like factors: three fingers in many pies". The Journal of Biological Chemistry. 276 (37): 34355–8. doi: 10.1074/jbc.R100043200 . PMID   11443140.

Further reading