MEOX2

Last updated
MEOX2
Identifiers
Aliases MEOX2 , GAX, MOX2, mesenchyme homeobox 2
External IDs OMIM: 600535; MGI: 103219; HomoloGene: 4330; GeneCards: MEOX2; OMA:MEOX2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005924

NM_008584

RefSeq (protein)

NP_005915

NP_032610

Location (UCSC) Chr 7: 15.61 – 15.69 Mb Chr 12: 37.16 – 37.23 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene. [5] [6]

Contents

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [6] MEOX2 has been implicated in the initiation of tumors in glioma. [7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance. [8] [9]

Interactions

MEOX2 has been shown to interact with PAX1 [10] and PAX3. [10]

Related Research Articles

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<span class="mw-page-title-main">Pax genes</span> Family of transcription factors

In evolutionary developmental biology, Paired box (Pax) genes are a family of genes coding for tissue specific transcription factors containing an N-terminal paired domain and usually a partial, or in the case of four family members, a complete homeodomain to the C-terminus. An octapeptide as well as a Pro-Ser-Thr-rich C terminus may also be present. Pax proteins are important in early animal development for the specification of specific tissues, as well as during epimorphic limb regeneration in animals capable of such.

<span class="mw-page-title-main">PAX3</span> Paired box gene 3

The PAX3 gene encodes a member of the paired box or PAX family of transcription factors. The PAX family consists of nine human (PAX1-PAX9) and nine mouse (Pax1-Pax9) members arranged into four subfamilies. Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. The human PAX3 gene is located in the 2q36.1 chromosomal region, and contains 10 exons within a 100 kb region.

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<span class="mw-page-title-main">HOXC8</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.

<span class="mw-page-title-main">HOXB2</span> Protein-coding gene in humans

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

<span class="mw-page-title-main">HOXB3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.

<span class="mw-page-title-main">HOXC4</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

<span class="mw-page-title-main">HOPX</span> Protein-coding gene in humans

Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. It is an important regulator of cardiac development and a marker of hippocampal neural stem cells.

<span class="mw-page-title-main">HOXB13</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene.

<span class="mw-page-title-main">PRRX1</span> Protein-coding gene in the species Homo sapiens

Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.

<span class="mw-page-title-main">PAX1</span> Protein-coding gene in humans

Paired box protein Pax-1 is a protein that in humans is encoded by the PAX1 gene.

<span class="mw-page-title-main">EMX2</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.

<span class="mw-page-title-main">HOXD1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

<span class="mw-page-title-main">HOXC11</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

<span class="mw-page-title-main">MEIS2</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

<span class="mw-page-title-main">NKX2-3</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.

<span class="mw-page-title-main">MEOX1</span> Protein-coding gene in the species Homo sapiens

Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.

<span class="mw-page-title-main">DUX4</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">DBX2</span> Protein-coding gene in humans

Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene. DBX2, a homeodomain-containing protein, plays an important role in the development of the central nervous system, specifically in the development of the neural tube and brain. The gene DBX2 is located on chromosome 12 and is approximately 36,000 base pairs long. DBX2 is predicted to enable DNA-binding transcription activity as well as being involved in the regulation of transcription by RNA polymerase II.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000106511 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036144 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. LePage DF, Altomare DA, Testa JR, Walsh K (December 1994). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–540. doi:10.1006/geno.1994.1663. PMID   7713505.
  6. 1 2 "Entrez Gene: MEOX2 mesenchyme homeobox 2".
  7. Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, et al. (April 2022). "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma". Cell Death & Disease. 13 (4): 360. doi:10.1038/s41419-022-04845-2. PMC   9016080 . PMID   35436995.
  8. Armas-López L, Piña-Sánchez P, Arrieta O, de Alba EG, Ortiz-Quintero B, Santillán-Doherty P, et al. (September 2017). "Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients". Oncotarget. 8 (40): 67056–67081. doi:10.18632/oncotarget.17715. PMC   5620156 . PMID   28978016.
  9. Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MD, Pineda-Villegas P, et al. (January 2022). "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer". European Journal of Cancer. 160: 189–205. doi:10.1016/j.ejca.2021.10.032. PMID   34844838.
  10. 1 2 Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (June 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters. 499 (3): 274–278. Bibcode:2001FEBSL.499..274S. doi: 10.1016/S0014-5793(01)02556-X . PMID   11423130. S2CID   40668112.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.