Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene. [5] [6]
Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene. [5] [6]
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [6] MEOX2 has been implicated in the initiation of tumors in glioma. [7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance. [8] [9]
MEOX2 has been shown to interact with PAX1 [10] and PAX3. [10]
Zinc finger protein GLI3 is a protein that in humans is encoded by the GLI3 gene.
In evolutionary developmental biology, Paired box (Pax) genes are a family of genes coding for tissue specific transcription factors containing an N-terminal paired domain and usually a partial, or in the case of four family members, a complete homeodomain to the C-terminus. An octapeptide as well as a Pro-Ser-Thr-rich C terminus may also be present. Pax proteins are important in early animal development for the specification of specific tissues, as well as during epimorphic limb regeneration in animals capable of such.
The PAX3 gene encodes a member of the paired box or PAX family of transcription factors. The PAX family consists of nine human (PAX1-PAX9) and nine mouse (Pax1-Pax9) members arranged into four subfamilies. Human PAX3 and mouse Pax3 are present in a subfamily along with the highly homologous human PAX7 and mouse Pax7 genes. The human PAX3 gene is located in the 2q36.1 chromosomal region, and contains 10 exons within a 100 kb region.
Paired-like homeodomain transcription factor 2 also known as pituitary homeobox 2 is a protein that in humans is encoded by the PITX2 gene.
Homeobox protein Hox-C8 is a protein that in humans is encoded by the HOXC8 gene.
Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.
Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.
Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.
Homeodomain-only protein is a protein that in humans is encoded by the HOPX gene. It is an important regulator of cardiac development and a marker of hippocampal neural stem cells.
Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene.
Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.
Paired box protein Pax-1 is a protein that in humans is encoded by the PAX1 gene.
Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.
Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.
Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.
Homeobox protein Nkx-2.3 is a protein that in humans is encoded by the NKX2-3 gene.
Homeobox protein MOX-1 is a protein that in humans is encoded by the MEOX1 gene.
Double homeobox, 4 also known as DUX4 is a protein which in humans is encoded by the DUX4 gene. Its misexpression is the cause of facioscapulohumeral muscular dystrophy (FSHD).
Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene. DBX2, a homeodomain-containing protein, plays an important role in the development of the central nervous system, specifically in the development of the neural tube and brain. The gene DBX2 is located on chromosome 12 and is approximately 36,000 base pairs long. DBX2 is predicted to enable DNA-binding transcription activity as well as being involved in the regulation of transcription by RNA polymerase II.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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