Homeobox A10

HOXA10
Identifiers
Aliases	HOXA10 , HOX1, HOX1.8, HOX1H, PL, Homeobox A10
External IDs	OMIM: 142957 MGI: 96171 HomoloGene: 7365 GeneCards: HOXA10
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7p15.2 Start 27,170,605 bp [1] End 27,180,261 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 B3|6 25.4 cM Start 52,208,177 bp [2] End 52,217,834 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii myometrium endometrium vastus lateralis muscle canal of the cervix muscle of leg gastrocnemius muscle triceps brachii muscle deltoid muscle Achilles tendon Top expressed in connecting tubule vas deferens Bowman's capsule hand proximal tubule elbow hip myometrium foot triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific histone deacetylase binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm transcription regulator complex nucleus Biological process skeletal system development proximal/distal pattern formation male gonad development regulation of transcription, DNA-templated transcription, DNA-templated single fertilization uterus development multicellular organism development embryonic limb morphogenesis spermatogenesis regulation of gene expression anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3206 15395 Ensembl ENSG00000253293 ENSMUSG00000000938 UniProt P31260 P31310 RefSeq (mRNA) NM_018951 NM_153715 NM_001122950 NM_008263 RefSeq (protein) NP_061824 NP_001116422 NP_032289 Location (UCSC) Chr 7: 27.17 – 27.18 Mb Chr 6: 52.21 – 52.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein Hox-A10 is a protein that in humans is encoded by the HOXA10 gene. ^{[5] [6] [7]}

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants encoding different isoforms have been described. ^[7] Downregulation of HOXA10 is observed in the human and baboon decidua after implantation and this downregulation promotes trophoblast invasion by activating STAT3 ^[8]

Interactions

Homeobox A10 has been shown to interact with PTPN6. ^[9]

See also

• Homeobox

References

1. GRCh38: Ensembl release 89: ENSG00000253293 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000938 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID   1973146.
6. Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID   1358459. S2CID   13370372.
7. "Entrez Gene: HOXA10 homeobox A10".
8. Godbole, Geeta; Suman, Pankaj; Malik, Ankita; Galvankar, Mosami; Joshi, Niraj; Fazleabas, Asgi; Gupta, Satish; Modi, Deepak (2017). "Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion". Endocrinology. 158 (8): 2618–2633. doi:10.1210/en.2017-00032. PMC   6283436 . PMID   28520923.
9. Eklund EA, Goldenberg I, Lu Y, Andrejic J, Kakar R (Sep 2002). "SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells". The Journal of Biological Chemistry. 277 (39): 36878–88. doi: 10.1074/jbc.M203917200 . PMID   12145285.

Further reading

• Eun Kwon H, Taylor HS (Dec 2004). "The role of HOX genes in human implantation". Annals of the New York Academy of Sciences. 1034 (1): 1–18. Bibcode:2004NYASA1034....1E. doi:10.1196/annals.1335.001. PMID   15731295. S2CID   41501204.
• Lowney P, Corral J, Detmer K, LeBeau MM, Deaven L, Lawrence HJ, Largman C (Jun 1991). "A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells". Nucleic Acids Research. 19 (12): 3443–9. doi:10.1093/nar/19.12.3443. PMC   328346 . PMID   1676505.
• Shen WF, Largman C, Lowney P, Corral JC, Detmer K, Hauser CA, Simonitch TA, Hack FM, Lawrence HJ (Nov 1989). "Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines". Proceedings of the National Academy of Sciences of the United States of America. 86 (21): 8536–40. Bibcode:1989PNAS...86.8536S. doi: 10.1073/pnas.86.21.8536 . PMC   298317 . PMID   2573064.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC   335308 . PMID   2574852.
• Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK (Dec 1994). "Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells". Proceedings of the National Academy of Sciences of the United States of America. 91 (25): 12223–7. Bibcode:1994PNAS...9112223S. doi: 10.1073/pnas.91.25.12223 . PMC   45409 . PMID   7527557.
• Lawrence HJ, Sauvageau G, Ahmadi N, Lopez AR, LeBeau MM, Link M, Humphries K, Largman C (Oct 1995). "Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells". Experimental Hematology. 23 (11): 1160–6. PMID   7556525.
• Satokata I, Benson G, Maas R (Mar 1995). "Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice". Nature. 374 (6521): 460–3. Bibcode:1995Natur.374..460S. doi:10.1038/374460a0. PMID   7700356. S2CID   4337017.
• Castronovo V, Kusaka M, Chariot A, Gielen J, Sobel M (Jan 1994). "Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype". Biochemical Pharmacology. 47 (1): 137–43. doi:10.1016/0006-2952(94)90447-2. PMID   7906121.
• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1–2): 114–5. doi:10.1159/000134320. PMID   8646877.
• Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK (Jan 1997). "Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia". Molecular and Cellular Biology. 17 (1): 495–505. doi:10.1128/mcb.17.1.495. PMC   231774 . PMID   8972230.
• Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology. 17 (11): 6448–58. doi:10.1128/MCB.17.11.6448. PMC   232497 . PMID   9343407.
• Taylor HS, Vanden Heuvel GB, Igarashi P (Dec 1997). "A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes". Biology of Reproduction. 57 (6): 1338–45. doi: 10.1095/biolreprod57.6.1338 . PMID   9408238.
• Taylor HS, Arici A, Olive D, Igarashi P (Apr 1998). "HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium". The Journal of Clinical Investigation. 101 (7): 1379–84. doi:10.1172/JCI1057. PMC   508715 . PMID   9525980.
• Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE (May 1999). "Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells". Leukemia. 13 (5): 687–98. doi: 10.1038/sj/leu/2401410 . PMID   10374871.
• Eklund EA, Jalava A, Kakar R (Jun 2000). "Tyrosine phosphorylation of HoxA10 decreases DNA binding and transcriptional repression during interferon gamma -induced differentiation of myeloid leukemia cell lines". The Journal of Biological Chemistry. 275 (26): 20117–26. doi: 10.1074/jbc.M907915199 . PMID   10766757.
• Buske C, Feuring-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, Humphries RK (Apr 2001). "Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo". Blood. 97 (8): 2286–92. doi: 10.1182/blood.V97.8.2286 . PMID   11290589.
• Cermik D, Karaca M, Taylor HS (Jul 2001). "HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract". The Journal of Clinical Endocrinology and Metabolism. 86 (7): 3387–92. doi: 10.1210/jcem.86.7.7675 . PMID   11443215. S2CID   23775476.
• Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC   99922 . PMID   11585930.

^{[1] [2]}

External links

• HOXA10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

1. Godbole, Geeta; Modi, Deepak (2010). "Regulation of decidualization, interleukin-11 and interleukin-15 by homeobox A 10 in endometrial stromal cells". American Journal of Reproductive Immunology. 85 (2): 130–9. doi:10.1016/j.jri.2010.03.003. PMID   20478621.
2. Godbole, Geeta; Puri, CP; Modi, Deepak (2007). "Regulation of homeobox A10 expression in the primate endometrium by progesterone and embryonic stimuli". Reproduction. 134 (3): 513–23. doi: 10.1530/REP-07-0234 . PMID   17709569.