TBPL1

TBPL1
Identifiers
Aliases	TBPL1 , MGC:8389, MGC:9620, STUD, TLF, TLP, TRF2, TATA-box binding protein like 1
External IDs	OMIM: 605521 MGI: 1339946 HomoloGene: 3577 GeneCards: TBPL1
Gene location (Human)
Chr.	Chromosome 6 (human)
End	133,990,432 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	22,731,938 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• DNA binding ; • GO:0001105 transcription coactivator activity ; • GO:0001948 protein binding ; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding ; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific ; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific ; • RNA polymerase II core promoter sequence-specific DNA binding ; • RNA polymerase III transcription regulatory region sequence-specific DNA binding ; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity ; • transcription factor binding ;
Cellular component	• cytoplasm ; • transcription factor TFIIA complex ; • nucleus ; • transcription factor TFIIIB complex ; • transcription regulator complex ; • transcription factor TFIID complex ;
Biological process	• spermatid nucleus differentiation ; • regulation of transcription, DNA-templated ; • transcription by RNA polymerase II ; • acrosome assembly ; • dTTP biosynthetic process ; • transcription, DNA-templated ; • spermatogenesis ; • DNA-templated transcription, initiation ; • positive regulation of transcription by RNA polymerase II ; • RNA polymerase III preinitiation complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	9519
	237336
	ENSG00000028839
	ENSMUSG00000071359
	P62380 ; Q7Z6T9
	P62340
	NM_004865 ; NM_001253676
	NM_011603
	NP_001240605 ; NP_004856
	NP_035733
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 22, 2021

TATA box-binding protein-like protein 1 is a protein that in humans is encoded by the TBPL1 gene.^[5]^[6]^[7]^[8]

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.^[8]

Interactions

TBPL1 has been shown to interact with GTF2A1.^[9]^[10]

Related Research Articles

In molecular biology, the TATA box is a sequence of DNA found in the core promoter region of genes in archaea and eukaryotes. The bacterial homolog of the TATA box is called the Pribnow box which has a shorter consensus sequence.

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

Transcription factor II D (TF_IID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins. Before the start of transcription, the transcription Factor II D (TFIID) complex binds to the TATA box in the core promoter of the gene.

Transcription initiation factor TFIID subunit 6 is a protein that in humans is encoded by the TAF6 gene.

Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a protein that in humans is encoded by the TAF9 gene.

Transcription initiation factor TFIID subunit 12 is a protein that in humans is encoded by the TAF12 gene.

Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.

Transcription initiation factor TFIID subunit 2 is a protein that in humans is encoded by the TAF2 gene.

Transcription initiation factor TFIID subunit 10 is a protein that in humans is encoded by the TAF10 gene.

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

Transcription initiation factor TFIID subunit 11 also known as TAFII28, is a protein that in humans is encoded by the TAF11 gene.

TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the TAF15 gene.

Dr1-associated corepressor is a protein that in humans is encoded by the DRAP1 gene.

TATA-binding protein-associated factor 172 is a protein that in humans is encoded by the BTAF1 gene.

Transcription initiation factor TFIID subunit 13 is a protein that in humans is encoded by the TAF13 gene.

TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the TAF6L gene.

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.

Transcription initiation factor TFIID subunit 9B is a protein that in humans is encoded by the TAF9B gene.

TATA-box binding protein like 2 is a protein that in humans is encoded by the TBPL2 gene. The TBPL2 protein is also known as TBP-related factor 3 (TRF3) and TATA binding protein 2 (TBP2). The protein was independently discovered in three laboratories as a vertebrate-specific family member of TATA-binding protein (TBP). Orthologs have been identified in mouse, frog and fish. Whereas the TBP gene is found in all eukaryotes, TBPL2 is only found in vertebrates.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000028839 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071359 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T (Feb 1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochemical and Biophysical Research Communications. 255 (1): 137–42. doi:10.1006/bbrc.1999.0159. PMID 10082669.
↑ Rabenstein MD, Zhou S, Lis JT, Tjian R (Apr 1999). "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4791–6. Bibcode:1999PNAS...96.4791R. doi: 10.1073/pnas.96.9.4791 . PMC 21770 . PMID 10220372.
↑ Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE (Apr 2005). "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP". Molecular and Cellular Biology. 25 (7): 2632–43. doi:10.1128/MCB.25.7.2632-2643.2005. PMC 1061635 . PMID 15767669.
1 2 "Entrez Gene: TBPL1 TBP-like 1".
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
↑ Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13720–5. Bibcode:1999PNAS...9613720T. doi: 10.1073/pnas.96.24.13720 . PMC 24131 . PMID 10570139.

External links

TBPL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000028839 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071359 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10082669-5] Ohbayashi T, Kishimoto T, Makino Y, Shimada M, Nakadai T, Aoki T, Kawata T, Niwa S, Tamura T (Feb 1999). "Isolation of cDNA, chromosome mapping, and expression of the human TBP-like protein". Biochemical and Biophysical Research Communications. 255 (1): 137–42. doi:10.1006/bbrc.1999.0159. PMID 10082669.

[pmid10220372-6] Rabenstein MD, Zhou S, Lis JT, Tjian R (Apr 1999). "TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4791–6. Bibcode:1999PNAS...96.4791R. doi: 10.1073/pnas.96.9.4791 . PMC 21770 . PMID 10220372.

[pmid15767669-7] Chong JA, Moran MM, Teichmann M, Kaczmarek JS, Roeder R, Clapham DE (Apr 2005). "TATA-binding protein (TBP)-like factor (TLF) is a functional regulator of transcription: reciprocal regulation of the neurofibromatosis type 1 and c-fos genes by TLF/TRF2 and TBP". Molecular and Cellular Biology. 25 (7): 2632–43. doi:10.1128/MCB.25.7.2632-2643.2005. PMC 1061635 . PMID 15767669.

[entrez-8] 1 2 "Entrez Gene: TBPL1 TBP-like 1".

[pmid17353931-9] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

[pmid10570139-10] Teichmann M, Wang Z, Martinez E, Tjernberg A, Zhang D, Vollmer F, Chait BT, Roeder RG (Nov 1999). "Human TATA-binding protein-related factor-2 (hTRF2) stably associates with hTFIIA in HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13720–5. Bibcode:1999PNAS...9613720T. doi: 10.1073/pnas.96.24.13720 . PMC 24131 . PMID 10570139.

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