Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene. [5] [6]
Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene. [5] [6]
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes. [6]
LIM homeobox transcription factor 1-beta, also known as LMX1B, is a protein which in humans is encoded by the LMX1B gene.
PDX1, also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.
HNF1 homeobox B, also known as HNF1B or transcription factor 2 (TCF2), is a human gene.
C-jun-amino-terminal kinase-interacting protein 1 is an enzyme that in humans is encoded by the MAPK8IP1 gene.
Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.
Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the ISL1 gene.
Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.
Homeobox protein DLX-3 is a protein that in humans is encoded by the DLX3 gene.
Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.
Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.
Paired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.
Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.
Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.
Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.
Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene.
Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.
Transcription factor MafA is a protein that in humans is encoded by the MAFA gene. It is a member of the Maf family of transcription factors.
Neurogenin-3 (NGN3) is a protein that in humans is encoded by the Neurog3 gene.
Short-stature homeobox 2, also known as homeobox protein Og12X or paired-related homeobox protein SHOT, is a protein that in humans is encoded by the SHOX2 gene.
Regulatory factor X, 6 also known as DNA-binding protein RFX6 is a protein that in humans is encoded by the RFX6 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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