ZNF41

ZNF41
Identifiers
Aliases	ZNF41 , MRX89, zinc finger protein 41
External IDs	OMIM: 314995 HomoloGene: 133263 GeneCards: ZNF41
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.3 Start 47,445,178 bp [1] End 47,483,222 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of leg gastrocnemius muscle islet of Langerhans rectum ganglionic eminence monocyte left ventricle appendix smooth muscle tissue Achilles tendon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component intracellular anatomical structure nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7592 n/a Ensembl ENSG00000147124 n/a UniProt P51814 n/a RefSeq (mRNA) NM_007130 NM_153380 NM_001324139 NM_001324140 NM_001324141 NM_001324142 NM_001324143 NM_001324144 NM_001324145 NM_001324147 NM_001324148 NM_001324149 NM_001324150 NM_001324151 NM_001324152 NM_001324153 NM_001324154 NM_001324155 NM_001324156 NM_001324157 n/a RefSeq (protein) NP_001311068 NP_001311069 NP_001311070 NP_001311071 NP_001311072 NP_001311073 NP_001311074 NP_001311076 NP_001311077 NP_001311078 NP_001311079 NP_001311080 NP_001311081 NP_001311082 NP_001311083 NP_001311084 NP_001311085 NP_001311086 NP_009061 NP_700359 n/a Location (UCSC) Chr X: 47.45 – 47.48 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene. ^{[3] [4]}

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known. ^[4]

References

1. GRCh38: Ensembl release 89: ENSG00000147124 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Franze A, Archidiacono N, Rocchi M, Marino M, Grimaldi G (Jul 1991). "Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome". Genomics. 9 (4): 728–36. doi:10.1016/0888-7543(91)90367-N. PMID   2037297.
4. "Entrez Gene: ZNF41 zinc finger protein 41".

Further reading

• Rosati M, Marino M, Franzè A, et al. (1991). "Members of the zinc finger protein gene family sharing a conserved N-terminal module". Nucleic Acids Res. 19 (20): 5661–7. doi:10.1093/nar/19.20.5661. PMC   328972 . PMID   1945843.
• Knight JC, Grimaldi G, Thiesen HJ, et al. (1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics. 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID   8088786.
• Rosati M, Franzé A, Matarazzo MR, Grimaldi G (1999). "Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41". Cytogenet. Cell Genet. 85 (3–4): 291–6. doi:10.1159/000015315. PMID   10449920. S2CID   26777065.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Shoichet SA, Hoffmann K, Menzel C, et al. (2004). "Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation". Am. J. Hum. Genet. 73 (6): 1341–54. doi:10.1086/380309. PMC   1180399 . PMID   14628291.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC   2665286 . PMID   15772651.

External links

• ZNF41+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.