SOX6

Last updated
SOX6
PBB Protein SOX6 image.jpg
Identifiers
Aliases SOX6 , HSSOXD, SRY-box 6, SRY-box transcription factor 6, TOLCAS
External IDs OMIM: 607257; MGI: 98368; HomoloGene: 22631; GeneCards: SOX6; OMA:SOX6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 11: 15.97 – 16.74 Mb Chr 7: 115.47 – 116.04 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene. [5] [6]

Contents

Function

The SOX gene family encodes a group of transcription factors defined by the conserved high mobility group (HMG) DNA-binding domain. Unlike most transcription factors, SOX transcription factors bind to the minor groove of DNA, causing a 70- to 85-degree bend and introducing local conformational changes.[supplied by OMIM] [6]

Interactions

SOX6 has been shown to interact with CTBP2 [7] and CENPK. [8]

It has also been demonstrated that SOX6 protein accumulates in the differentiating human erythrocytes, and then is able to downregulate its own transcription, by directly binding to an evolutionarily conserved consensus sequences located near SOX6 transcriptional start site. [9]

Sox6 appears to have a crucial role in the transcriptional regulation of globin genes, and in directing the terminal differentiation of red blood cells. [10] In addition, SOX6 may have a role in tumor growth of Ewing sarcoma. [11] A new role of Sox6 in renin and prorenin regulation was studied using a Sox KO mouse model in which Sox6 is only knockout in renin expressing cells. This study showed that renin promoter possesses the binding site for Sox6. The highlight of the study was that Sox6 is one of the key regulators of renin and prorenin regulation and JG cell expansion during low salt and dehydration in mice. PMID 31760770; DOI: 10.1152/ajprenal.00095.2019

See also

Related Research Articles

SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box. This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.

<span class="mw-page-title-main">HMGA1</span> Protein-coding gene in the species Homo sapiens

High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene.

<span class="mw-page-title-main">FLI1</span> Protein-coding gene in the species Homo sapiens

Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene.

<span class="mw-page-title-main">ATF1</span> Protein-coding gene in humans

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

<span class="mw-page-title-main">Y box binding protein 1</span> Protein-coding gene in the species Homo sapiens

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene. YBX1 is an RNA binding protein that stabilises messenger RNAs modified with N6-methyladenosine.

<span class="mw-page-title-main">KLF5</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

<span class="mw-page-title-main">SOX3</span> Protein-coding gene in the species Homo sapiens

Transcription factor SOX-3 is a protein that in humans is encoded by the SOX3 gene. This gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic brain development and in determination of cell fate. The encoded protein acts as a transcriptional activator.

<span class="mw-page-title-main">SOX5</span> Protein-coding gene in Homo sapiens

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.

<span class="mw-page-title-main">GTF3A</span> Protein-coding gene in the species Homo sapiens

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.

<span class="mw-page-title-main">SOX18</span> Protein-coding gene in the species Homo sapiens

Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.

<span class="mw-page-title-main">CEBPG</span> Protein-coding gene in the species Homo sapiens

CCAAT/enhancer-binding protein gamma (C/EBPγ) is a protein that in humans is encoded by the CEBPG gene. This gene has no introns.

<span class="mw-page-title-main">NFIX</span> Protein-coding gene in the species Homo sapiens

Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.

<span class="mw-page-title-main">MAFF (gene)</span> Protein-coding gene

Transcription factor MafF is a bZip Maf transcription factor protein that in humans is encoded by the MAFF gene.

<span class="mw-page-title-main">SOX8</span> Protein-coding gene in the species Homo sapiens

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

<span class="mw-page-title-main">RFX4</span> Protein-coding gene in the species Homo sapiens

Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.

<span class="mw-page-title-main">KLF8</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

<span class="mw-page-title-main">POU2F3</span> Protein-coding gene in the species Homo sapiens

POU domain, class 2, transcription factor 3 is a protein that in humans is encoded by the POU2F3 gene.

<span class="mw-page-title-main">GFI1B</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein Gfi-1b is a protein that in humans is encoded by the GFI1B gene.

<span class="mw-page-title-main">ZNF366</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 366, also known as DC-SCRIPT, is a protein that in humans is encoded by the ZNF366 gene. The ZNF366 gene was first identified in a DNA comparison study between 85 kb of Fugu rubripes sequence containing 17 genes with its homologous loci in the human draft genome.

<span class="mw-page-title-main">SOX12</span> Protein-coding gene in the species Homo sapiens

SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000110693 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051910 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cohen-Barak O, Hagiwara N, Arlt MF, Horton JP, Brilliant MH (March 2001). "Cloning, characterization and chromosome mapping of the human SOX6 gene". Gene. 265 (1–2): 157–164. doi:10.1016/S0378-1119(01)00346-8. PMID   11255018.
  6. 1 2 "Entrez Gene: SOX6 SRY (sex determining region Y)-box 6".
  7. Murakami A, Ishida S, Thurlow J, Revest JM, Dickson C (August 2001). "SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter". Nucleic Acids Research. 29 (16): 3347–3355. doi:10.1093/nar/29.16.3347. PMC   55854 . PMID   11504872.
  8. Yamashita A, Ito M, Takamatsu N, Shiba T (September 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–151. Bibcode:2000FEBSL.481..147Y. doi: 10.1016/S0014-5793(00)01987-6 . PMID   10996314. S2CID   20831354.
  9. Cantu' C, Grande V, Alborelli I, Cassinelli L, Cantu' I, Colzani MT, et al. (January 2011). "A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells". Nucleic Acids Research. 39 (2): 486–501. doi:10.1093/nar/gkq819. PMC   3025548 . PMID   20852263.
  10. Cantù C, Ierardi R, Alborelli I, Fugazza C, Cassinelli L, Piconese S, et al. (March 2011). "Sox6 enhances erythroid differentiation in human erythroid progenitors". Blood. 117 (13): 3669–3679. doi: 10.1182/blood-2010-04-282350 . PMID   21263153.
  11. Marchetto A, Ohmura S, Orth MF, Knott MM, Colombo MV, Arrigoni C, et al. (May 2020). "Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma". Nature Communications. 11 (1): 2423. Bibcode:2020NatCo..11.2423M. doi: 10.1038/s41467-020-16244-2 . PMC   7228971 . PMID   32415069.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.