ZNF10

ZNF10
Identifiers
Aliases	ZNF10 , KOX1, zinc finger protein 10
External IDs	OMIM: 194538; HomoloGene: 130674; GeneCards: ZNF10; OMA:ZNF10 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	133,159,465 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; testicle; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gonad; ; left ovary; ; right uterine tube; ; right ovary; ; body of pancreas; ; gastric mucosa;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding ; protein binding ; metal ion binding ; nucleic acid binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	intracellular anatomical structure ; nucleus ;
Biological process	regulation of transcription, DNA-templated ; transcription, DNA-templated ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	7556
	n/a
	ENSG00000256223
	n/a
	P21506
	n/a
	NM_015394
	n/a
	NP_056209
	n/a
	Wikidata
View/Edit Human

Last updated August 23, 2024

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.^[3]^[4]^[5]

Function

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein.^[5]

Interactions

ZNF10 has been shown to interact with TRIM28.^[6]^[7]

Related Research Articles

The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors. The KRAB domain typically consists of about 75 amino acid residues, while the minimal repression module is approximately 45 amino acid residues. It is predicted to function through protein-protein interactions via two amphipathic helices. The most prominent interacting protein is called TRIM28 initially visualized as SMP1, cloned as KAP1 and TIF1-beta. Substitutions for the conserved residues abolish repression.

In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family.

Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1, is a protein that in humans is encoded by the TRIM28 gene.

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

Zinc finger protein 350 is a protein that in humans is encoded by the ZNF350 gene.

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.

Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.

Zinc finger protein with KRAB and SCAN domains 1 is a protein that in humans is encoded by the ZKSCAN1 gene.

Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.

Zinc finger protein 268 is a protein that in humans is encoded by the ZNF268 gene. ZNF268 is associated with cervical cancer.

Zinc finger protein 16 is a protein that in humans is encoded by the ZNF16 gene.

Zinc finger protein 23 is a protein that in humans is encoded by the ZNF23 gene.

Zinc finger protein 133 is a protein that in humans is encoded by the ZNF133 gene.

Zinc finger protein 224 is a protein that in humans is encoded by the ZNF224 gene.

Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene.

Zinc finger protein 184, also known as ZNF184, is a protein that in humans is encoded by the ZNF184 gene on chromosome 6. It was first identified by Goldwurm et al. in 1996.

Zinc finger protein 226 is a protein that in humans is encoded by the ZNF226 gene.

Zinc finger protein 684 is a protein that in humans is encoded by the ZNF684 gene.

Zinc Finger Protein 548 (ZNF548) is a human protein encoded by the ZNF548 gene which is located on chromosome 19. It is found in the nucleus and is hypothesized to play a role in the regulation of transcription by RNA Polymerase II. It belongs to the Krüppel C2H2-type zinc-finger protein family as it contains many zinc-finger repeats.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000256223 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
↑ Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R (Dec 1993). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Human Genetics. 92 (6): 583–7. doi:10.1007/BF00420943. PMID 8262519. S2CID 19201834.
1 2 "Entrez Gene: ZNF10 zinc finger protein 10".
↑ Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Research. 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346 . PMID 9016654.
↑ Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry. 275 (24): 18000–10. doi: 10.1074/jbc.M001499200 . PMID 10748030.

External links

ZNF10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000256223 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7865130-3] Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.

[pmid8262519-4] Rousseau-Merck MF, Hillion J, Jonveaux P, Couillin P, Seité P, Thiesen HJ, Berger R (Dec 1993). "Chromosomal localization of 9 KOX zinc finger genes: physical linkages suggest clustering of KOX genes on chromosomes 12, 16, and 19". Human Genetics. 92 (6): 583–7. doi:10.1007/BF00420943. PMID 8262519. S2CID 19201834.

[entrez-5] 1 2 "Entrez Gene: ZNF10 zinc finger protein 10".

[pmid9016654-6] Moosmann P, Georgiev O, Le Douarin B, Bourquin JP, Schaffner W (Dec 1996). "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Research. 24 (24): 4859–67. doi:10.1093/nar/24.24.4859. PMC 146346 . PMID 9016654.

[pmid10748030-7] Peng H, Begg GE, Harper SL, Friedman JR, Speicher DW, Rauscher FJ (Jun 2000). "Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain". The Journal of Biological Chemistry. 275 (24): 18000–10. doi: 10.1074/jbc.M001499200 . PMID 10748030.

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