GTF2E2

Last updated
GTF2E2
PDB 1d8k EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GTF2E2 , FE, TF2E2, TFIIE-B, TTD6, general transcription factor IIE subunit 2
External IDs OMIM: 189964 MGI: 1915403 HomoloGene: 37573 GeneCards: GTF2E2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002095
NM_001348353

NM_001167921
NM_001167922
NM_026584

RefSeq (protein)

NP_002086
NP_001335282

NP_001161393
NP_001161394
NP_080860

Location (UCSC) Chr 8: 30.58 – 30.66 Mb Chr 8: 34.22 – 34.27 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

General transcription factor IIE subunit 2 (GTF2E2), also known as transcription initiation factor IIE subunit beta (TFIIE-beta), is a protein that in humans is encoded by the GTF2E2 gene. [5]

See also

Related Research Articles

Transcription preinitiation complex Complex of proteins necessary for gene transcription in eukaryotes and archaea

The preinitiation complex is a complex of approximately 100 proteins that is necessary for the transcription of protein-coding genes in eukaryotes and archaea. The preinitiation complex positions RNA polymerase II at gene transcription start sites, denatures the DNA, and positions the DNA in the RNA polymerase II active site for transcription.

General transcription factor Class of protein transcription factors

General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific sites (promoter) on DNA to activate transcription of genetic information from DNA to messenger RNA. GTFs, RNA polymerase, and the mediator constitute the basic transcriptional apparatus that first bind to the promoter, then start transcription. GTFs are also intimately involved in the process of gene regulation, and most are required for life.

TATA-binding protein Protein-coding gene in the species Homo sapiens

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene promoters.

Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.

POLR2E

DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the POLR2E gene.

SUPT5H

Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene.

TAF7

Transcription initiation factor TFIID subunit 7 also known as TAFII55 is a protein that in humans is encoded by the TAF7 gene.

TAF5

Transcription initiation factor TFIID subunit 5 is a protein that in humans is encoded by the TAF5 gene.

GTF3C2

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.

GTF3C1

General transcription factor 3C polypeptide 1 is a protein that in humans is encoded by the GTF3C1 gene.

POLR3F

DNA-directed RNA polymerase III subunit RPC6 is an enzyme that in humans is encoded by the POLR3F gene.

SNAPC3 Protein-coding gene in the species Homo sapiens

snRNA-activating protein complex subunit 3 is a protein that in humans is encoded by the SNAPC3 gene.

SNAPC2

snRNA-activating protein complex subunit 2 is a protein that in humans is encoded by the SNAPC2 gene.

GTF2F1

General transcription factor IIF subunit 1 is a protein that in humans is encoded by the GTF2F1 gene.

GTF2F2

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene.

POLR3C

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.

Transcription factor IIIB 50 kDa subunit

Transcription factor IIIB 50 kDa subunit (TFIIIB50) also known as b-related factor 2 (BRF-2) is a protein that in humans is encoded by the BRF2 gene.

GTF2A1

Transcription initiation factor IIA subunit 1 is a protein that in humans is encoded by the GTF2A1 gene.

GTF2E1

General transcription factor IIE subunit 1 (GTF2E1), also known as transcription initiation factor IIE subunit alpha (TFIIE-alpha), is a protein that in humans is encoded by the GTF2E1 gene.

Selective factor 1

Selective factor 1 is a transcription factor that binds to the promoter of genes and recruits a preinitiation complex to which RNA polymerase I will bind to and begin the transcription of ribosomal RNA (rRNA).

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197265 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031585 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: general transcription factor IIE".

Further reading