PHF1

PHF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5P, 2M0O, 4HCZ
Identifiers
Aliases	PHF1 , MTF2L2, PCL1, PHF2, TDRD19C, hPHD finger protein 1
External IDs	OMIM: 602881 MGI: 98647 HomoloGene: 7567 GeneCards: PHF1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.32 Start 33,410,399 bp [1] End 33,416,453 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A3.3|17 13.6 cM Start 27,152,026 bp [2] End 27,156,882 bp [2]
RNA expression pattern Bgee Top expressed in pituitary gland anterior pituitary left lobe of thyroid gland right lobe of thyroid gland canal of the cervix gastric mucosa popliteal artery prostate fundus hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity metal ion binding methylated histone binding GO:0001948 protein binding chromatin binding nucleosome binding sequence-specific DNA binding Cellular component cytoplasm site of double-strand break ESC/E(Z) complex nucleoplasm microtubule organizing center cytoskeleton nucleus centrosome Biological process negative regulation of histone H3-K27 methylation regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus regulation of histone methylation negative regulation of gene expression, epigenetic positive regulation of histone H3-K27 methylation chromatin organization positive regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5252	21652
Ensembl	ENSG00000112511 ENSG00000225553 ENSG00000239756	ENSMUSG00000024193
UniProt	O43189	Q9Z1B8
RefSeq (mRNA)	NM_002636 NM_024165	NM_009343 NM_001302397
RefSeq (protein)	NP_002627 NP_077084	NP_001289326 NP_033369
Location (UCSC)	Chr 6: 33.41 – 33.42 Mb	Chr 17: 27.15 – 27.16 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene. ^{[5] [6] [7]}

Function

This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene. ^[7]

References

1. ENSG00000225553, ENSG00000239756 GRCh38: Ensembl release 89: ENSG00000112511, ENSG00000225553, ENSG00000239756 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024193 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Coulson M, Robert S, Eyre HJ, Saint R (March 1998). "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics. 48 (3): 381–3. doi:10.1006/geno.1997.5201. PMID   9545646.
6. Hong Z, Jiang J, Lan L, Nakajima S, Kanno S, Koseki H, Yasui A (May 2008). "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research. 36 (9): 2939–47. doi:10.1093/nar/gkn146. PMC   2396414 . PMID   18385154.
7. "Entrez Gene: PHF1 PHD finger protein 1".

Further reading

• Cao R, Wang H, He J, Erdjument-Bromage H, Tempst P, Zhang Y (March 2008). "Role of hPHF1 in H3K27 methylation and Hox gene silencing". Molecular and Cellular Biology. 28 (5): 1862–72. doi:10.1128/MCB.01589-07. PMC   2258785 . PMID   18086877.
• O'Connell S, Wang L, Robert S, Jones CA, Saint R, Jones RS (November 2001). "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein". The Journal of Biological Chemistry. 276 (46): 43065–73. doi: 10.1074/jbc.M104294200 . PMID   11571280.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.

External links

• PHF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.