TAL2

TAL2
Identifiers
Aliases	TAL2 , TAL bHLH transcription factor 2
External IDs	OMIM: 186855 MGI: 99540 HomoloGene: 3954 GeneCards: TAL2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	105,663,124 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	53,788,712 bp
RNA expression pattern
	Top expressed in
	vastus lateralis muscle; ; deltoid muscle; ; renal medulla; ; ganglionic eminence; ; gastrocnemius muscle; ; kidney; ; mesencephalon; ; metanephros; ; jejunum; ; substantia nigra;
	Top expressed in
	pineal gland; ; temporal muscle; ; spermatid; ; hair follicle; ; seminiferous tubule; ; skeletal muscle tissue; ; esophagus; ; quadriceps femoris muscle; ; sexually immature organism; ; medullary collecting duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding ; RNA polymerase II transcription regulatory region sequence-specific DNA binding ; protein binding ; protein dimerization activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ;
Cellular component	nucleus ;
Biological process	regulation of transcription, DNA-templated ; post-embryonic development ; transcription, DNA-templated ; midbrain development ; multicellular organism growth ; thalamus development ; regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	6887
	21350
	ENSG00000186051
	ENSMUSG00000028417
	Q16559
	Q62282
	NM_005421
	NM_009317
	NP_005412
	NP_033343
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.^[5]^[6]

Function

TAL2 is a member of the basic helix-loop-helix family of transcription factors.^[7]

Clinical significance

Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).^[6]^[8]

Related Research Articles

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene.

Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.

DNA-binding protein inhibitor ID-2 is a protein that in humans is encoded by the ID2 gene.

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene.

LIM domain only 2, also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

SCL-interrupting locus protein is a protein that in humans is encoded by the STIL gene.

Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene.

T-cell leukemia homeobox protein 3 is a protein that in humans is encoded by the TLX3 gene.

Phosphatidylinositol binding clathrin assembly protein, also known as PICALM, is a protein which in humans is encoded by the PICALM gene.

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.

Transcriptional activator protein Pur-beta is a protein that in humans is encoded by the PURB gene.

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.

Transcription factor AP-4 , also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.

Putative RNA-binding protein 15 is a protein that in humans is encoded by the RBM15 gene. It is a RNA-binding protein that acts as a key regulator of N6-Methyladenosine (m⁶A) methylation of RNAs

Twist-related protein 2 is a protein that in humans is encoded by the TWIST2 gene. The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor and shares similarity with another bHLH transcription factor, TWIST1. bHLH transcription factors have been implicated in cell lineage determination and differentiation. It is thought that during osteoblast development, this protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype.

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Helix-loop-helix protein 1 is a protein that in humans is encoded by the NHLH1 gene.

Neurogenin-2 is a protein that in humans is encoded by the NEUROG2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186051 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028417 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2".
1 2 Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi: 10.1073/pnas.88.24.11416 . PMC 53146 . PMID 1763056.
↑ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.
↑ Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187. S2CID 20213008.

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Marculescu R, Vanura K, Le T, et al. (2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187. S2CID 20213008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Xia Y, Hwang LY, Cobb MH, Baer R (1994). "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity". Oncogene. 9 (5): 1437–46. PMID 8152805.
Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422 . PMID 7957052.
Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi: 10.1073/pnas.88.24.11416 . PMC 53146 . PMID 1763056.
Goldfarb AN, Goueli S, Mickelson D, Greenberg JM (1992). "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein". Blood. 80 (11): 2858–66. doi: 10.1182/blood.V80.11.2858.bloodjournal80112858 . PMID 1450410.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186051 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028417 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2".

[Xia_1991-6] 1 2 Xia Y, Brown L, Yang CY, Tsan JT, Siciliano MJ, Espinosa R, Le Beau MM, Baer RJ (December 1991). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. Bibcode:1991PNAS...8811416X. doi: 10.1073/pnas.88.24.11416 . PMC 53146 . PMID 1763056.

[Baer_1993-7] Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.

[Marculescu_2003-8] Marculescu R, Vanura K, Le T, Simon P, Jäger U, Nadel B (March 2003). "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. doi:10.1038/ng1092. PMID 12567187. S2CID 20213008.

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TAL2

Contents

Function

Clinical significance

Related Research Articles

References

Further reading