PROP1

PROP1
Identifiers
Aliases	PROP1 , CPHD2, PROP-1, PROP paired-like homeobox 1
External IDs	OMIM: 601538; MGI: 109330; HomoloGene: 4558; GeneCards: PROP1; OMA:PROP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.3 Start 177,992,235 bp [1] End 177,996,242 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11 B1.3|11 30.95 cM Start 50,841,633 bp [2] End 50,844,592 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pituitary Gland anterior pituitary Top expressed in anterior pituitary Rathke's pouch embryo pars distalis of adenohypophysis blastocyst lumbar spinal ganglion digastric muscle lumbar subsegment of spinal cord carotid body spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding beta-catenin binding chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein C-terminus binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus Biological process regulation of transcription, DNA-templated somatotropin secreting cell differentiation hypothalamus cell differentiation hypophysis morphogenesis negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II adenohypophysis development central nervous system development blood vessel development animal organ morphogenesis canonical Wnt signaling pathway dorsal/ventral pattern formation cell migration positive regulation of transcription by RNA polymerase II gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5626 19127 Ensembl ENSG00000280635 ENSG00000175325 ENSG00000274382 ENSMUSG00000044542 UniProt O75360 P97458 RefSeq (mRNA) NM_006261 NM_008936 RefSeq (protein) NP_006252 NP_032962 Location (UCSC) Chr 5: 177.99 – 178 Mb Chr 11: 50.84 – 50.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene. ^{[5] [6]}

PROP1 has both DNA-binding and transcriptional activation ability. Its expression leads to ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes, and caudomedial thyrotropes. Inactivating mutations in PROP1 result in deficiencies of luteinizing hormone (LH; MIM 152780), follicle-stimulating hormone (FSH; MIM 136530), growth hormone (GH; MIM 139250), prolactin (PRL; MIM 176760), and thyroid-stimulating hormone (TSH; MIM 188540). See combined pituitary hormone deficiency (CPHD; MIM 262600).[supplied by OMIM] ^[6]

References

1. ENSG00000175325, ENSG00000274382 GRCh38: Ensembl release 89: ENSG00000280635, ENSG00000175325, ENSG00000274382 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044542 – Ensembl, May 2017
3. '"`UNIQ--templatestyles-00000007-QINU`"' "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. '"`UNIQ--templatestyles-00000009-QINU`"' "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wu W, Cogan JD, Pfaffle RW, Dasen JS, Frisch H, O'Connell SM, Flynn SE, Brown MR, Mullis PE, Parks JS, Phillips JA III, Rosenfeld MG (Feb 1998). "Mutations in PROP1 cause familial combined pituitary hormone deficiency". Nat Genet. 18 (2): 147–9. doi:10.1038/ng0298-147. PMID   9462743. S2CID   6882625.
6. "Entrez Gene: PROP1 prophet of Pit1, paired-like homeodomain transcription factor".

Further reading

• Osorio MG, Kopp P, Marui S, et al. (2000). "Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1". J. Clin. Endocrinol. Metab. 85 (8): 2779–85. doi: 10.1210/jcem.85.8.6744 . PMID   10946881.
• Dasen JS, Rosenfeld MG (2001). "Signaling and transcriptional mechanisms in pituitary development". Annu. Rev. Neurosci. 24 (1): 327–55. doi:10.1146/annurev.neuro.24.1.327. PMID   11283314. S2CID   19902876.
• Mody S, Brown MR, Parks JS (2003). "The spectrum of hypopituitarism caused by PROP1 mutations". Best Pract. Res. Clin. Endocrinol. Metab. 16 (3): 421–31. doi:10.1053/beem.2002.0218. PMID   12464226.
• Rodriguez R, Andersen B (2003). "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency". Minerva Endocrinol. 28 (2): 123–33. PMID   12717343.
• Fofanova O, Takamura N, Kinoshita E, et al. (1998). "Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency". J. Clin. Endocrinol. Metab. 83 (7): 2601–4. doi: 10.1210/jcem.83.7.5094 . PMID   9661653.
• Amendt BA, Sutherland LB, Semina EV, Russo AF (1998). "The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities". J. Biol. Chem. 273 (32): 20066–72. doi: 10.1074/jbc.273.32.20066 . PMID   9685346.
• Cogan JD, Wu W, Phillips JA, et al. (1998). "The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency" (PDF). J. Clin. Endocrinol. Metab. 83 (9): 3346–9. doi:10.1210/jcem.83.9.5142. hdl: 10400.17/2282 . PMID   9745452.
• Flück C, Deladoey J, Rutishauser K, et al. (1998). "Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg→Cys at codon 120 (R120C)". J. Clin. Endocrinol. Metab. 83 (10): 3727–34. doi: 10.1210/jcem.83.10.5172 . PMID   9768691. S2CID   10386868.
• Duquesnoy P, Roy A, Dastot F, et al. (1998). "Human Prop-1: cloning, mapping, genomic structure. Mutations in familial combined pituitary hormone deficiency". FEBS Lett. 437 (3): 216–20. doi: 10.1016/S0014-5793(98)01234-4 . PMID   9824293. S2CID   20169741.
• Rosenbloom AL, Almonte AS, Brown MR, et al. (1999). "Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene". J. Clin. Endocrinol. Metab. 84 (1): 50–7. doi: 10.1210/jcem.84.1.5366 . PMID   9920061. S2CID   35502053.
• Mendonca BB, Osorio MG, Latronico AC, et al. (1999). "Longitudinal hormonal and pituitary imaging changes in two females with combined pituitary hormone deficiency due to deletion of A301,G302 in the PROP1 gene". J. Clin. Endocrinol. Metab. 84 (3): 942–5. doi: 10.1210/jcem.84.3.5537 . PMID   10084575. S2CID   22748592.
• Nakamura Y, Usui T, Mizuta H, et al. (1999). "Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans". J. Clin. Endocrinol. Metab. 84 (4): 1414–9. doi: 10.1210/jcem.84.4.5630 . PMID   10199788.
• Deladoëy J, Flück C, Büyükgebiz A, et al. (1999). ""Hot spot" in the PROP1 gene responsible for combined pituitary hormone deficiency". J. Clin. Endocrinol. Metab. 84 (5): 1645–50. doi: 10.1210/jcem.84.5.5681 . PMID   10323394. S2CID   2891639.
• Agarwal G, Bhatia V, Cook S, Thomas PQ (2001). "Adrenocorticotropin deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion". J. Clin. Endocrinol. Metab. 85 (12): 4556–61. doi: 10.1210/jcem.85.12.7013 . PMID   11134108.
• Vallette-Kasic S, Barlier A, Teinturier C, et al. (2001). "PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency". J. Clin. Endocrinol. Metab. 86 (9): 4529–35. doi: 10.1210/jcem.86.9.7811 . PMID   11549703.
• Teinturier C, Vallette S, Adamsbaum C, et al. (2002). "Pseudotumor of the pituitary due to PROP-1 deletion". J. Pediatr. Endocrinol. Metab. 15 (1): 95–101. doi:10.1515/jpem.2002.15.1.95. PMID   11822586. S2CID   9184549.
• Crone J, Pfäffle R, Stobbe H, et al. (2002). "Familial combined pituitary hormone deficiency caused by PROP-1 gene mutation. Growth patterns and MRI studies in untreated subjects". Horm. Res. 57 (3–4): 120–6. doi:10.1159/000057962. PMID   12006708. S2CID   8619602.

External links

• GeneReviews/NCBI/NIH/UW entry on PROP1- Related Combined Pituitary Hormone Deficiency (CPHD)
• PROP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.